Pifithrin-α | Enzo Life Sciences BML-GR325-0005 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

Pifithrin-α

catalog :

BML-GR325-0005

quantity :

5 mg

citations: 8

Reference
Murphy P, Galigniana M, Morishima Y, Harrell J, Kwok R, Ljungman M, et al. Pifithrin-alpha inhibits p53 signaling after interaction of the tumor suppressor protein with hsp90 and its nuclear translocation. J Biol Chem. 2004;279:30195-201 pubmed
Muller F, Loser K, Kleideiter U, Neumann J, von Wallbrunn C, Dobner T, et al. Transcription factor AP-2alpha triggers apoptosis in cardiac myocytes. Cell Death Differ. 2004;11:485-93 pubmed
Javelaud D, Besancon F. Inactivation of p21WAF1 sensitizes cells to apoptosis via an increase of both p14ARF and p53 levels and an alteration of the Bax/Bcl-2 ratio. J Biol Chem. 2002;277:37949-54 pubmed
Alves da Costa C, Paitel E, Mattson M, Amson R, Telerman A, Ancolio K, et al. Wild-type and mutated presenilins 2 trigger p53-dependent apoptosis and down-regulate presenilin 1 expression in HEK293 human cells and in murine neurons. Proc Natl Acad Sci U S A. 2002;99:4043-8 pubmed
Lakkaraju A, Dubinsky J, Low W, Rahman Y. Neurons are protected from excitotoxic death by p53 antisense oligonucleotides delivered in anionic liposomes. J Biol Chem. 2001;276:32000-7 pubmed
Komarova E, Gudkov A. Suppression of p53: a new approach to overcome side effects of antitumor therapy. Biochemistry (Mosc). 2000;65:41-8 pubmed
Ferber D. Cancer research. A new way to combat therapy side effects. Science. 1999;285:1651, 1653 pubmed
Komarov P, Komarova E, Kondratov R, Christov Tselkov K, Coon J, Chernov M, et al. A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Science. 1999;285:1733-7 pubmed

product information

Product ID :

BML-GR325

Catalog Number :

BML-GR325-0005

Product Name :

Pifithrin-α

Product Type :

Biochemical

Size :

5 mg

list of Pubmed id :

15145929, 14752511, 12151395, 11904448, 11406618, 10702639, 10523177, 10481009

Product Description :

Chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in models of stroke and neurodegenerative disorders. Suppresses self-renewal of embryonic stem cells.

ALTnames :

1-(4-Methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone . HBr, PFT-α

Purity :

≥98% (TLC)

Storage :

-20°C