Trichostatin A | Enzo Life Sciences BML-GR309-0001 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

Trichostatin A

catalog :

BML-GR309-0001

quantity :

1 mg

citations: 10

Reference
Di Zanni E, Fornasari D, Ravazzolo R, Ceccherini I, Bachetti T. Identification of novel pathways and molecules able to down-regulate PHOX2B gene expression by in vitro drug screening approaches in neuroblastoma cells. Exp Cell Res. 2015;336:43-57 pubmed publisher
Huber K, Doyon G, Plaks J, Fyne E, Mellors J, Sluis Cremer N. Inhibitors of histone deacetylases: correlation between isoform specificity and reactivation of HIV type 1 (HIV-1) from latently infected cells. J Biol Chem. 2011;286:22211-8 pubmed publisher
Snykers S, Vanhaecke T, De Becker A, Papeleu P, Vinken M, Van Riet I, et al. Chromatin remodeling agent trichostatin A: a key-factor in the hepatic differentiation of human mesenchymal stem cells derived of adult bone marrow. BMC Dev Biol. 2007;7:24 pubmed
Hosseinkhani M, Hasegawa K, Ono K, Kawamura T, Takaya T, Morimoto T, et al. Trichostatin A induces myocardial differentiation of monkey ES cells. Biochem Biophys Res Commun. 2007;356:386-91 pubmed
Vigushin D, Ali S, Pace P, Mirsaidi N, Ito K, Adcock I, et al. Trichostatin A is a histone deacetylase inhibitor with potent antitumor activity against breast cancer in vivo. Clin Cancer Res. 2001;7:971-6 pubmed
Bhakat K, Mitra S. Regulation of the human O(6)-methylguanine-DNA methyltransferase gene by transcriptional coactivators cAMP response element-binding protein-binding protein and p300. J Biol Chem. 2000;275:34197-204 pubmed
Marks P, Richon V, Rifkind R. Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells. J Natl Cancer Inst. 2000;92:1210-6 pubmed
Gray S, Ekstrom T. Effects of cell density and trichostatin A on the expression of HDAC1 and p57Kip2 in Hep 3B cells. Biochem Biophys Res Commun. 1998;245:423-7 pubmed
Brehm A, Miska E, McCance D, Reid J, Bannister A, Kouzarides T. Retinoblastoma protein recruits histone deacetylase to repress transcription. Nature. 1998;391:597-601 pubmed
Sowa Y, Orita T, Minamikawa S, Nakano K, Mizuno T, Nomura H, et al. Histone deacetylase inhibitor activates the WAF1/Cip1 gene promoter through the Sp1 sites. Biochem Biophys Res Commun. 1997;241:142-50 pubmed

product information

Product ID :

BML-GR309

Catalog Number :

BML-GR309-0001

Product Name :

Trichostatin A

Product Type :

Biochemical

Size :

1 mg

list of Pubmed id :

25882494, 21531716, 17407549, 17368572, 11309348, 10942771, 10922406, 9571167, 9468139, 9405248

Product Description :

Trichostatin A (TSA) is a potent and reversible inhibitor of histone deacetylases. In HeLa cells, TSA blocked cell cycle progression at G1 and induced a 12-fold increase in intracellular levels of gelsolin. In cells latently infected with HIV-1, TSA induced the transcriptional activation of the HIV-1 promoter, which resulted in a marked increase in virus production. In NIH 3T3 cells, TSA induced reversion of oncogenic ras-transformed cells to a normal morphology. In Jurkat cells, TSA inhibited IL-2 gene expression (IC50=73nM) and displayed immunosuppressive activity in a mouse model. Induces increased acetylation of GATA4, a cardiac-specific transcription factor and increases cardiac muscle cell differentiation. Trichostatin A is a useful tool for induction of hyperacetylation of cellular histones and for further elucidation of their role in gene expression. Induces cell growth arrest at both G1 and G2/M phases. may induce apoptosis in some cases. It can induce accelerated dedifferentiation of primordial germ cells into embryonic germ cells.

ALTnames :

[R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide

Purity :

≥98% (HPLC)

Storage :

-20°C