Actinomycin D | Enzo Life Sciences BML-GR300-0005 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

Actinomycin D

catalog :

BML-GR300-0005

quantity :

5 mg

citations: 10

Reference
He T, Hatem E, Vernis L, Lei M, Huang M. PRX1 knockdown potentiates vitamin K3 toxicity in cancer cells: a potential new therapeutic perspective for an old drug. J Exp Clin Cancer Res. 2015;34:152 pubmed publisher
Pfister A, Keil M, KÃ¼hl M. The Wnt Target Protein Peter Pan Defines a Novel p53-independent Nucleolar Stress-Response Pathway. J Biol Chem. 2015;290:10905-18 pubmed publisher
Wang M, Liu S, Liu Y, Zheng D. Actinomycin D enhances TRAIL-induced caspase-dependent and -independent apoptosis in SH-SY5Y neuroblastoma cells. Neurosci Res. 2007;59:40-6 pubmed
Kalousek I, Brodska B, Otevrelova P, Roselova P. Actinomycin D upregulates proapoptotic protein Puma and downregulates Bcl-2 mRNA in normal peripheral blood lymphocytes. Anticancer Drugs. 2007;18:763-72 pubmed
Mischo H, Hemmerich P, Grosse F, Zhang S. Actinomycin D induces histone gamma-H2AX foci and complex formation of gamma-H2AX with Ku70 and nuclear DNA helicase II. J Biol Chem. 2005;280:9586-94 pubmed
Qing C, Miao Z, Tong L, Zhang J, Ding J. Actinomycin D inhibiting K562 cell apoptosis elicited by salvicine but not decreasing its cytotoxicity. Acta Pharmacol Sin. 2003;24:415-21 pubmed
Kleeff J, Kornmann M, Sawhney H, Korc M. Actinomycin D induces apoptosis and inhibits growth of pancreatic cancer cells. Int J Cancer. 2000;86:399-407 pubmed
Akahori M, Yamada S, Takeyama N, Tanaka T. Nitric oxide ameliorates actinomycin D/endotoxin-induced apoptotic liver failure in mice. J Surg Res. 1999;85:286-93 pubmed
Bailey S, Graves D, Rill R, Marsch G. Influence of DNA base sequence on the binding energetics of actinomycin D. Biochemistry. 1993;32:5881-7 pubmed
Verhaegen S, McGowan A, Brophy A, Fernandes R, Cotter T. Inhibition of apoptosis by antioxidants in the human HL-60 leukemia cell line. Biochem Pharmacol. 1995;50:1021-9 pubmed

product information

Product ID :

BML-GR300

Catalog Number :

BML-GR300-0005

Product Name :

Actinomycin D

Product Type :

Biochemical

Size :

5 mg

list of Pubmed id :

26689287, 25759387, 17707539, 17581298, 15613478, 12740176, 10760829, 10423331, 8504108, 7575657

Product Description :

An intercalating transcription inhibitor and antineoplastic antibiotic. Inhibits transcription by binding to DNA at dG residues. Induces apoptosis in many cell lines, but suppresses in PC12 cells induced by topoisomrease II inhibitor etopside. Used at 5-10µg/ml in cell culture for haltiong transcription. The product is not sterile.

Purity :

≥98% (TLC)

Storage :

-20°C