TCPOBOP | Enzo Life Sciences BML-GR245-0025 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

TCPOBOP

catalog :

BML-GR245-0025

quantity :

25 mg

citations: 3

Reference
Petrick J, Klaassen C. Importance of hepatic induction of constitutive androstane receptor and other transcription factors that regulate xenobiotic metabolism and transport. Drug Metab Dispos. 2007;35:1806-15 pubmed
Baskin Bey E, Huang W, Ishimura N, Isomoto H, Bronk S, Braley K, et al. Constitutive androstane receptor (CAR) ligand, TCPOBOP, attenuates Fas-induced murine liver injury by altering Bcl-2 proteins. Hepatology. 2006;44:252-62 pubmed
Diwan B, Lubet R, Ward J, Hrabie J, Rice J. Tumor-promoting and hepatocarcinogenic effects of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) in DBA/2NCr and C57BL/6NCr mice and an apparent promoting effect on nasal cavity tumors but not on hepatocellular tumors in F344/NCr rats initiated. Carcinogenesis. 1992;13:1893-901 pubmed

product information

Product ID :

BML-GR245

Catalog Number :

BML-GR245-0025

Product Name :

TCPOBOP

Product Type :

Biochemical

Size :

25 mg

list of Pubmed id :

17627975, 16799968, 1330346

Product Description :

TCPOBOP is an activator of the mouse constitutive androstane receptor (CAR) and a potent inducer of cytochrome P450 monoxygenase activity. Has been shown to have a potent tumor-promoting activity and hepatocarcinogenic effects in mice but not in rats.

ALTnames :

1,4-Bis-[2-(3,5-dichloropyridyloxy)]benzene

Purity :

≥98% (TLC)

Storage :

Ambient