Troglitazone | Enzo Life Sciences BML-GR210-0005 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

Troglitazone

catalog :

BML-GR210-0005

quantity :

5 mg

citations: 9

Reference
Ye J, Yin L, Xie P, Wu J, Huang J, Zhou G, et al. Antiproliferative effects and molecular mechanisms of troglitazone in human cervical cancer in vitro. Onco Targets Ther. 2015;8:1211-8 pubmed publisher
Declercq V, d Eon B, McLeod R. Fatty acids increase adiponectin secretion through both classical and exosome pathways. Biochim Biophys Acta. 2015;1851:1123-33 pubmed publisher
Lindstrom T, Bennett P. 15-Deoxy-{delta}12,14-prostaglandin j2 inhibits interleukin-1{beta}-induced nuclear factor-{kappa}b in human amnion and myometrial cells: mechanisms and implications. J Clin Endocrinol Metab. 2005;90:3534-43 pubmed
Tchoukalova Y, Hausman D, Dean R, Hausman G. Enhancing effect of troglitazone on porcine adipocyte differentiation in primary culture: a comparison with dexamethasone. Obes Res. 2000;8:664-72 pubmed
Okura T, Nakamura M, Takata Y, Watanabe S, Kitami Y, Hiwada K. Troglitazone induces apoptosis via the p53 and Gadd45 pathway in vascular smooth muscle cells. Eur J Pharmacol. 2000;407:227-35 pubmed
Fujiwara T, Horikoshi H. Troglitazone and related compounds: therapeutic potential beyond diabetes. Life Sci. 2000;67:2405-16 pubmed
Guan Y, Zhang Y, Breyer R, Davis L, Breyer M. Expression of peroxisome proliferator-activated receptor gamma (PPARgamma) in human transitional bladder cancer and its role in inducing cell death. Neoplasia. 1999;1:330-9 pubmed
Tsubouchi Y, Sano H, Kawahito Y, Mukai S, Yamada R, Kohno M, et al. Inhibition of human lung cancer cell growth by the peroxisome proliferator-activated receptor-gamma agonists through induction of apoptosis. Biochem Biophys Res Commun. 2000;270:400-5 pubmed
Asou H, Verbeek W, Williamson E, Elstner E, Kubota T, Kamada N, et al. Growth inhibition of myeloid leukemia cells by troglitazone, a ligand for peroxisome proliferator activated receptor gamma, and retinoids. Int J Oncol. 1999;15:1027-31 pubmed

product information

Product ID :

BML-GR210

Catalog Number :

BML-GR210-0005

Product Name :

Troglitazone

Product Type :

Biochemical

Size :

5 mg

list of Pubmed id :

26060406, 25900100, 15755849, 11225715, 11068018, 11065164, 10944516, 10935488, 10753637, 10536188

Product Description :

Antidiabetic thiazolidinedione. Potent and selective PPARγ ligand. Binds to the PPARγ ligand-binding domain and recruits ligand-specific transcriptional coactivators at 1µM. In skeletal muscle and adipocyte cell cultures, the EC50 of troglitazone is about 10µM. Displaces [125I]SB-236636 with an IC50=7.9µM. Stimulates adipogenesis and decreases osteoblastogenesis in human mesenchymal stem cells. Induces apoptosis in human vascular smooth muscle cells and inhibits the growth of a variety of human cancer cells including lung, bladder and myeloid leukemia cells. Displays an anti-invasive effect on human breast cancer cells; reduces migration, adhesion and spreading on fibronectin-coated plates. Inhibits cell growth of hematopoietic cell lines. Inhibits lamellipodia formation and actin polymerization.

ALTnames :

(±)-5-[[4-[(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl]-2,4-thiazolidinedione

Purity :

≥98% (HPLC)

Storage :

Ambient