Glutamic acid decarboxylase polyclonal antibody | Enzo Life Sciences BML-GC3008-0025 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

Glutamic acid decarboxylase polyclonal antibody

catalog :

BML-GC3008-0025

quantity :

25 µl

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry

product information

Product ID :

BML-GC3008

Catalog Number :

BML-GC3008-0025

Product Name :

Glutamic acid decarboxylase polyclonal antibody

Host species :

Rabbit

Clonality :

Polyclonal

Product Type :

Antibody

Size :

25 µl

list of Pubmed id :

23013868, 20434539

SPECIES REACTIVITY :

Human, Mouse, Rat, Cat

Background :

Glutamic acid decarboxylase (GAD; E.C. 4.1.1.15) is the enzyme responsible for the conversion of glutamic acid to γ-aminobutyric acid (GABA) - the major inhibitory transmitter in higher brain regions. Two molecular forms of GAD (GAD65 and GAD67) are known from rat, cat, pig and man, and both forms are expressed in the CNS and in pancreatic islet endocrine cells. A recent Western blotting study has identified that the isoforms are regionally distributed in the brains of rats and mice. In rat pancreas, GAD65 and GAD67 appear to be differentially localised, GAD65 primarily in insulin-containing (β) cells and GAD67 in glucagon-containing (A) cells. Evidence from knock-out mice suggests that GABA generated by pancreatic GAD isoforms is not critically involved in normal islet cell development and morphology. However, β-cell-specific GAD expression has been shown to be required for the development of autoimmune diabetes in non-obese diabetic (NOD) mice.

ALTnames :

GAD

Immunogen :

Synthetic peptide corresponding to aa 572-585 (D572FLIEEIERLGQDL585) of rat glutamate decarboxylase (GAD65). This sequence is conserved in rat GAD67 and in human GAD-2.

Buffer :

Liquid. In PBS containing 0.09% sodium azide.

Uses :

Detects two isoforms of ~65kDa and ~67 kDa by Western Blot.

Application Summary :

ELISA, IHC, WB

Storage :

-20°C