Brefeldin A | Enzo Life Sciences BML-G405-0005 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

Brefeldin A

catalog :

BML-G405-0005

quantity :

5 mg

citations: 10

Reference
Zhang F, Wang Z, Li M, Lan Y, Chen Y, Wang C. Puerarin attenuates smoke inhalation injury by regulation of Th1/Th2 expression and inhibition of Th17 cells in rats. Int Immunopharmacol. 2015;28:546-53 pubmed publisher
Xu K, Shen X, Li H, Pacheco Rodriguez G, Moss J, Vaughan M. Interaction of BIG2, a brefeldin A-inhibited guanine nucleotide-exchange protein, with exocyst protein Exo70. Proc Natl Acad Sci U S A. 2005;102:2784-9 pubmed
Singleton V, Bohonos N, ULLSTRUP A. Decumbin, a new compound from a species of Penicillium. Nature. 1958;181:1072-3 pubmed
Stober D, Jomantaite I, Schirmbeck R, Reimann J. NKT cells provide help for dendritic cell-dependent priming of MHC class I-restricted CD8+ T cells in vivo. J Immunol. 2003;170:2540-8 pubmed
Nebenführ A, Ritzenthaler C, Robinson D. Brefeldin A: deciphering an enigmatic inhibitor of secretion. Plant Physiol. 2002;130:1102-8 pubmed
Chardin P, McCormick F. Brefeldin A: the advantage of being uncompetitive. Cell. 1999;97:153-5 pubmed
Shao R, Shimizu T, Pommier Y. Brefeldin A is a potent inducer of apoptosis in human cancer cells independently of p53. Exp Cell Res. 1996;227:190-6 pubmed
Fisher R, Grillo F, Sariban Sohraby S. Brefeldin A inhibition of apical Na+ channels in epithelia. Am J Physiol. 1996;270:C138-47 pubmed
Randazzo P, Yang Y, Rulka C, Kahn R. Activation of ADP-ribosylation factor by Golgi membranes. Evidence for a brefeldin A- and protease-sensitive activating factor on Golgi membranes. J Biol Chem. 1993;268:9555-63 pubmed
Ripley C, Fant J, Bienkowski R. Brefeldin A inhibits degradation as well as production and secretion of collagen in human lung fibroblasts. J Biol Chem. 1993;268:3677-82 pubmed

product information

Product ID :

BML-G405

Catalog Number :

BML-G405-0005

Product Name :

Brefeldin A

Product Type :

Biochemical

Size :

5 mg

list of Pubmed id :

26218281, 15705715, 13541371, 12594280, 12427977, 10219235, 8831555, 8772439, 8486645, 8429043

Product Description :

Inhibitor of intracellular protein transport and protein secretion, interfering with trafficking in the trans-Golgi network, leading to the accumulation of cycling proteins in ERGIC clusters. Blocks ADP-ribosylation factor (Arf) in an inactive GDP-bound conformation and thereby prevents binding of COPI coats to ERGIC and Golgi membranes. Upon brefeldin A treatment the Golgi rapidly tubulates and fuses with the ER by an energy-, temperature-, and microtubule-dependent process. In contrast, the drug has little effect on the ERGIC, which keeps its identity, although the ERGIC clusters become larger and more uniformly distributed in the cytoplasm of the cells. Inhibits intracellular collagen degradation. Also inhibits apical Na+ channels in epithelia. Induces apoptosis.

ALTnames :

BFA, Ascotoxin, Decumbin

Purity :

≥98% (HPLC)

Storage :

-20°C