Simvastatin | Enzo Life Sciences BML-G244-0250 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

Simvastatin

catalog :

BML-G244-0250

quantity :

250 mg

citations: 7

Reference
Wang C, Chen T, Li G, Zhou L, Sha S, Chen L. Simvastatin prevents Î²-amyloid(25-35)-impaired neurogenesis in hippocampal dentate gyrus through Î±7nAChR-dependent cascading PI3K-Akt and increasing BDNF via reduction of farnesyl pyrophosphate. Neuropharmacology. 2015;97:122-32 pubmed publisher
Wang H, Lynch J, Song P, Yang H, Yates R, Mace B, et al. Simvastatin and atorvastatin improve behavioral outcome, reduce hippocampal degeneration, and improve cerebral blood flow after experimental traumatic brain injury. Exp Neurol. 2007;206:59-69 pubmed
Chopra V, Choksi P, Cavusoglu E. Beyond lipid lowering: the anti-hypertensive role of statins. Cardiovasc Drugs Ther. 2007;21:161-9 pubmed
Xu H, Zeng L, Peng H, Chen S, Jones J, Chew T, et al. HMG-CoA reductase inhibitor simvastatin mitigates VEGF-induced "inside-out" signaling to extracellular matrix by preventing RhoA activation. Am J Physiol Renal Physiol. 2006;291:F995-1004 pubmed
Blanco Colio L, Tunon J, Martin Ventura J, Egido J. Anti-inflammatory and immunomodulatory effects of statins. Kidney Int. 2003;63:12-23 pubmed
Danesh F, Sadeghi M, Amro N, Philips C, Zeng L, Lin S, et al. 3-Hydroxy-3-methylglutaryl CoA reductase inhibitors prevent high glucose-induced proliferation of mesangial cells via modulation of Rho GTPase/ p21 signaling pathway: Implications for diabetic nephropathy. Proc Natl Acad Sci U S A. 2002;99:8301-5 pubmed
Wojcik C, Bury M, Stoklosa T, Giermasz A, Feleszko W, Mlynarczuk I, et al. Lovastatin and simvastatin are modulators of the proteasome. Int J Biochem Cell Biol. 2000;32:957-65 pubmed

product information

Product ID :

BML-G244

Catalog Number :

BML-G244-0250

Product Name :

Simvastatin

Product Type :

Biochemical

Size :

250 mg

list of Pubmed id :

26051402, 17521631, 17468937, 16774905, 12472764, 12048257, 11084375

Product Description :

HMG-CoA reductase inhibitor. Synthetic analog of Lovastatin (Prod. No. BML-G226). Inhibits the biosynthesis of isoprenoids and prevents small G protein activation. Displays lipid lowering and antihypertensive effects. Displays antiinflammatory, immunomodulatory effects as well as protective effects in experimental traumatic brain injury. Activates Rac1-dependent signalling pathway.

Purity :

≥98% (TLC)

Storage :

-20°C