Cerulenin | Enzo Life Sciences BML-G237-0025 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

Cerulenin

catalog :

BML-G237-0025

quantity :

25 mg

citations: 10

Reference
Zhou L, Yu Y, Chen X, Diab A, Ruan L, He J, et al. The Multiple DSF-family QS Signals are Synthesized from Carbohydrate and Branched-chain Amino Acids via the FAS Elongation Cycle. Sci Rep. 2015;5:13294 pubmed publisher
Ho T, Ho Y, Wong W, Chi Ming Chiu L, Wong Y, Eng Choon Ooi V. Fatty acid synthase inhibitors cerulenin and C75 retard growth and induce caspase-dependent apoptosis in human melanoma A-375 cells. Biomed Pharmacother. 2007;61:578-87 pubmed
Zhu G, Li Y, Cai X, Millership J, Marchewka M, Keithly J. Expression and functional characterization of a giant Type I fatty acid synthase (CpFAS1) gene from Cryptosporidium parvum. Mol Biochem Parasitol. 2004;134:127-35 pubmed
Yasuno R, von Wettstein Knowles P, Wada H. Identification and molecular characterization of the beta-ketoacyl-[acyl carrier protein] synthase component of the Arabidopsis mitochondrial fatty acid synthase. J Biol Chem. 2004;279:8242-51 pubmed
Heiligtag S, Bredehorst R, David K. Key role of mitochondria in cerulenin-mediated apoptosis. Cell Death Differ. 2002;9:1017-25 pubmed
Makimura H, Mizuno T, Yang X, Silverstein J, Beasley J, Mobbs C. Cerulenin mimics effects of leptin on metabolic rate, food intake, and body weight independent of the melanocortin system, but unlike leptin, cerulenin fails to block neuroendocrine effects of fasting. Diabetes. 2001;50:733-9 pubmed
Schneider F, Lessire R, Bessoule J, Juguelin H, Cassagne C. Effect of cerulenin on the synthesis of very-long-chain fatty acids in microsomes from leek seedlings. Biochim Biophys Acta. 1993;1152:243-52 pubmed
Metz S, Rabaglia M, Stock J, Kowluru A. Modulation of insulin secretion from normal rat islets by inhibitors of the post-translational modifications of GTP-binding proteins. Biochem J. 1993;295 ( Pt 1):31-40 pubmed
Inokoshi J, Tomoda H, Hashimoto H, Watanabe A, Takeshima H, Omura S. Cerulenin-resistant mutants of Saccharomyces cerevisiae with an altered fatty acid synthase gene. Mol Gen Genet. 1994;244:90-6 pubmed
Sato Y, Nomura S, Kamio Y, Omura S, Hata T. Studies on cerulenin, 3. Isolation and physico-chemical properties of cerulenin. J Antibiot (Tokyo). 1967;20:344-8 pubmed

product information

Product ID :

BML-G237

Catalog Number :

BML-G237-0025

Product Name :

Cerulenin

Product Type :

Biochemical

Size :

25 mg

list of Pubmed id :

26289160, 17904792, 14747150, 14660674, 12181752, 11289036, 8218325, 8216234, 8041367, 5631576

Product Description :

Antibiotic. Fatty acid synthase (FAS) inhibitor reported to bind in equimolar ratio to β-keto-acyl-ACP synthase (KAS; IC50=1.5µM), thus inhibiting protein acylation at concentrations of 45-134 µM. Produces metabolic effects similar to the effects of leptin, but through mechanisms that are independent of, or down-stream from, both leptin and melanocortin receptors. Apoptosis inducer. Inhibitor of bacterial fatty acid synthesis (inhibits FabH, FabB and FabF condensation enzymes).

ALTnames :

2,3-Epoxy-4-oxo-7,10-dodecadienamide

Purity :

≥98% (TLC)

Storage :

-20°C