Mevastatin | Enzo Life Sciences BML-G233-0050 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

Mevastatin

catalog :

BML-G233-0050

quantity :

50 mg

citations: 3

Reference
Quesney Huneeus V, Galick H, Siperstein M, Erickson S, Spencer T, Nelson J. The dual role of mevalonate in the cell cycle. J Biol Chem. 1983;258:378-85 pubmed
Endo A. The discovery and development of HMG-CoA reductase inhibitors. J Lipid Res. 1992;33:1569-82 pubmed
Quesney Huneeus V, Wiley M, Siperstein M. Essential role for mevalonate synthesis in DNA replication. Proc Natl Acad Sci U S A. 1979;76:5056-60 pubmed

product information

Product ID :

BML-G233

Catalog Number :

BML-G233-0050

Product Name :

Mevastatin

Product Type :

Biochemical

Size :

50 mg

list of Pubmed id :

6848509, 1464741, 291922

Product Description :

Mevastatin inhibits isoprenoid biosynthesis by inhibition of HMG-CoA reductase (Ki for acid form is 1 nM) and therefore blocks protein isoprenylation and reduces plasma cholesterol levels in humans. It causes cells to arrest early in the G1 phase. Mevastatin is a close structural analog of lovastatin and both agents have the same biochemical and pharmacological activities. Mevastatin is inactive in cell-free assays. In cells however, it is hydrolyzed to the active free acid form by intracellular esterases.

ALTnames :

Compactin

Purity :

≥95% (HPLC)

Storage :

-20°C