p53 (human), (recombinant) (GST-tag) | Enzo Life Sciences BML-FW9370-0050 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

protein

product name :

p53 (human), (recombinant) (GST-tag)

catalog :

BML-FW9370-0050

quantity :

50 µg

citations: 1

Reference
Nguyen D, Richter D, Michel G, Mitschka S, Kolanus W, Cuevas E, et al. The ubiquitin ligase LIN41/TRIM71 targets p53 to antagonize cell death and differentiation pathways during stem cell differentiation. Cell Death Differ. 2017;24:1063-1078 pubmed publisher

product information

Product ID :

BML-FW9370

Catalog Number :

BML-FW9370-0050

Product Name :

p53 (human), (recombinant) (GST-tag)

Product Type :

Protein

Size :

50 µg

Background :

p53 is a much studied and complex multifunctional protein, which acts as a tumor suppressor in many tumor types and induces growth arrest or apoptosis depending on the physiological circumstances and cell type. It is involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction appears to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. The p53 pathway responds to stresses that can disrupt the fidelity of DNA replication and cell division. A stress signal is transmitted to the p53 protein by post-translational modifications. Such modification results in the activation of p53 protein as a transcription factor that initiates a program of cell cycle arrest, cellular senescence or apoptosis.

ALTnames :

TRP53, Tumor protein p53

Purity :

≥90% (SDS-PAGE)

Buffer :

Liquid. In 50mM sodium phosphate, pH 7.5, containing 50mM sodium chloride.

Uses :

Useful for the study of postranslational modification of p53, or protein-protein interaction studies.

Storage :

-80°C