N-Arachidonylglycine | Enzo Life Sciences BML-FA029-0025 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

N-Arachidonylglycine

catalog :

BML-FA029-0025

quantity :

25 mg

citations: 6

Reference
McHugh D, Hu S, Rimmerman N, Juknat A, Vogel Z, Walker J, et al. N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor. BMC Neurosci. 2010;11:44 pubmed publisher
Kohno M, Hasegawa H, Inoue A, Muraoka M, Miyazaki T, Oka K, et al. Identification of N-arachidonylglycine as the endogenous ligand for orphan G-protein-coupled receptor GPR18. Biochem Biophys Res Commun. 2006;347:827-32 pubmed
Grazia Cascio M, Minassi A, Ligresti A, Appendino G, Burstein S, Di Marzo V. A structure-activity relationship study on N-arachidonoyl-amino acids as possible endogenous inhibitors of fatty acid amide hydrolase. Biochem Biophys Res Commun. 2004;314:192-6 pubmed
Huang S, Bisogno T, Petros T, Chang S, Zavitsanos P, Zipkin R, et al. Identification of a new class of molecules, the arachidonyl amino acids, and characterization of one member that inhibits pain. J Biol Chem. 2001;276:42639-44 pubmed
Burstein S, Rossetti R, Yagen B, Zurier R. Oxidative metabolism of anandamide. Prostaglandins Other Lipid Mediat. 2000;61:29-41 pubmed
Sheskin T, Hanus L, Slager J, Vogel Z, Mechoulam R. Structural requirements for binding of anandamide-type compounds to the brain cannabinoid receptor. J Med Chem. 1997;40:659-67 pubmed

product information

Product ID :

BML-FA029

Catalog Number :

BML-FA029-0025

Product Name :

N-Arachidonylglycine

Product Type :

Biochemical

Size :

25 mg

list of Pubmed id :

20346144, 16844083, 14715265, 11518719, 10785540, 9057852

Product Description :

Endogenous anandamide-like compound. Lacks affinity for CB1 receptors (Ki>10µM), TRPV1 (EC50>10µM) and anandamide uptake (IC50>50µM), but inhibits fatty acid amide hydrolase (FAAH) (IC50=8.5µM-50µM, depending on cell type and species). Displays anti-inflammatory and analgesic activity. Identified as an insulin secretagogue in a primary β-cell-based functional assay. Represents a new class of "lipoamino acids".

Purity :

≥98% (TLC)

Storage :

-20°C