This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
chemical
product name :
Stattic
catalog :
BML-EI368-0050
quantity :
50 mg
citations: 5
Reference
Brosig A, Kuhrt H, Wiedemann P, Kohen L, Bringmann A, Hollborn M. Gene expression regulation in retinal pigment epithelial cells induced by viral RNA and viral/bacterial DNA. Mol Vis. 2015;21:1000-16 pubmed
Hollborn M, Vogler S, Reichenbach A, Wiedemann P, Bringmann A, Kohen L. Regulation of the hyperosmotic induction of aquaporin 5 and VEGF in retinal pigment epithelial cells: involvement of NFAT5. Mol Vis. 2015;21:360-77 pubmed
Huang Y, Cheng S, Chueh S, Tsai Y, Liou N, Guo Y, et al. Effects of interleukin-15 on neuronal differentiation of neural stem cells. Brain Res. 2009;1304:38-48 pubmed publisher
Samavati L, Rastogi R, Du W, Huttemann M, Fite A, Franchi L. STAT3 tyrosine phosphorylation is critical for interleukin 1 beta and interleukin-6 production in response to lipopolysaccharide and live bacteria. Mol Immunol. 2009;46:1867-77 pubmed publisher
Schust J, Sperl B, Hollis A, Mayer T, Berg T. Stattic: a small-molecule inhibitor of STAT3 activation and dimerization. Chem Biol. 2006;13:1235-42 pubmed
product information
Product ID :
BML-EI368
Catalog Number :
BML-EI368-0050
Product Name :
Stattic
Product Type :
Biochemical
Size :
50 mg
list of Pubmed id :
26330750, 25878490, 19747902, 19299019, 17114005
Product Description :
Small molecule STAT3-specific inhibitor which blocks activation, dimerization and nuclear translocation via binding to the STAT3 SH2 domain. It is a very useful tool for exploring STAT3-mediated signaling pathways. It blocks LPS-mediated STAT3 tyrosine phosphorylation which leads to inhibition of LPS-mediated IL-1β and IL-6 production. In primary cultures of rat neural stem cells it blocks IL-15-induced differentiation.
ALTnames :
6-Nitro[b]thiophene-1,1-dioxide
Purity :
≥98% (TLC)
Storage :
Ambient
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.