AICAR | Enzo Life Sciences BML-EI330-0050 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

AICAR

catalog :

BML-EI330-0050

quantity :

50 mg

citations: 9

Reference
Wang G, Amato S, Gilbert J, Man H. Resveratrol up-regulates AMPA receptor expression via AMP-activated protein kinase-mediated protein translation. Neuropharmacology. 2015;95:144-53 pubmed publisher
Koo S, Flechner L, Qi L, Zhang X, Screaton R, Jeffries S, et al. The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism. Nature. 2005;437:1109-11 pubmed
Xiang X, Saha A, Wen R, Ruderman N, Luo Z. AMP-activated protein kinase activators can inhibit the growth of prostate cancer cells by multiple mechanisms. Biochem Biophys Res Commun. 2004;321:161-7 pubmed
Bronner M, Hertz R, Bar Tana J. Kinase-independent transcriptional co-activation of peroxisome proliferator-activated receptor alpha by AMP-activated protein kinase. Biochem J. 2004;384:295-305 pubmed
Jhun B, Jin Q, Oh Y, Kim S, Kong Y, Cho Y, et al. 5-Aminoimidazole-4-carboxamide riboside suppresses lipopolysaccharide-induced TNF-alpha production through inhibition of phosphatidylinositol 3-kinase/Akt activation in RAW 264.7 murine macrophages. Biochem Biophys Res Commun. 2004;318:372-80 pubmed
López J, Santidrian A, Campas C, Gil J. 5-Aminoimidazole-4-carboxamide riboside induces apoptosis in Jurkat cells, but the AMP-activated protein kinase is not involved. Biochem J. 2003;370:1027-32 pubmed
Habinowski S, Witters L. The effects of AICAR on adipocyte differentiation of 3T3-L1 cells. Biochem Biophys Res Commun. 2001;286:852-6 pubmed
Lochhead P, Salt I, Walker K, Hardie D, Sutherland C. 5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase. Diabetes. 2000;49:896-903 pubmed
Corton J, Gillespie J, Hawley S, Hardie D. 5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?. Eur J Biochem. 1995;229:558-65 pubmed

product information

Product ID :

BML-EI330

Catalog Number :

BML-EI330-0050

Product Name :

AICAR

Product Type :

Biochemical

Size :

50 mg

list of Pubmed id :

25791529, 16148943, 15358229, 15312046, 15120611, 12452797, 11527376, 10866040, 7744080

Product Description :

An adenosine analog that is phosphorylated in whole cells to form 5-aminoimidazole-4-carboxamide-1-D-ribofuranosyl-5’-monophosphate (ZMP), which stimulates AMPK activity. AICAR acts by entering nucleoside pools, significantly increasing levels of adenosine during periods of ATP breakdown. Induces the phosphorylation of TORC2 and inhibits its entry into the nucleus. Mimics the effects of insulin on the expression of two gluconeogenic genes PEPCK and glucose-6-phosphatase. Inhibits PPARα coactivation and adipocyte differentiation. Substrate for the AICAR transformylase activity of ATIC. Inhibits the growth of prostate cancer cells by inhibiting fatty ascid synthesis. Supresses LPS-induced TNF production via the inhibition of Akt activation. Induces apoptosis in Jurkat cells via a non-AMPK pathway.

ALTnames :

5-Aminoimidazole-4-carboxamide 1-β-D-ribofuranoside, Acadesine

Purity :

≥98% (TLC)

Storage :

-20°C