GW5074 | Enzo Life Sciences BML-EI307-0005 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

GW5074

catalog :

BML-EI307-0005

quantity :

5 mg

citations: 5

Reference
Huang J, Wu L, Tashiro S, Onodera S, Ikejima T. Fibroblast growth factor-2 suppresses oridonin-induced L929 apoptosis through extracellular signal-regulated kinase-dependent and phosphatidylinositol 3-kinase-independent pathway. J Pharmacol Sci. 2006;102:305-13 pubmed
Chang M, Chen B, Yu M, Sheu J, Chen T, Lin C. Phorbol 12-myristate 13-acetate upregulates cyclooxygenase-2 expression in human pulmonary epithelial cells via Ras, Raf-1, ERK, and NF-kappaB, but not p38 MAPK, pathways. Cell Signal. 2005;17:299-310 pubmed
Chen B, Yu C, Lei H, Chang M, Hsu M, Huang C, et al. Bradykinin B2 receptor mediates NF-kappaB activation and cyclooxygenase-2 expression via the Ras/Raf-1/ERK pathway in human airway epithelial cells. J Immunol. 2004;173:5219-28 pubmed
Chin P, Liu L, Morrison B, Siddiq A, Ratan R, Bottiglieri T, et al. The c-Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK-ERK and Akt-independent mechanism. J Neurochem. 2004;90:595-608 pubmed
Lackey K, Cory M, Davis R, Frye S, Harris P, Hunter R, et al. The discovery of potent cRaf1 kinase inhibitors. Bioorg Med Chem Lett. 2000;10:223-6 pubmed

product information

Product ID :

BML-EI307

Catalog Number :

BML-EI307-0005

Product Name :

GW5074

Product Type :

Biochemical

Size :

5 mg

list of Pubmed id :

17116975, 15567061, 15470067, 15255937, 10698440

Product Description :

Potent and selective cell permeable inhibitor of cRAF1 kinase (IC50 = 9 nM) with 100-fold selectivity over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. A useful tool for assessing the involvement of the Ras/Raf-1/ERK pathway in various signaling pathways. Displays neuroprotective effects in vivo through a MEK-ERK and Akt-independent mechanism.

ALTnames :

5-Iodo-3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-2-indolinone

Purity :

≥98% (TLC)

Storage :

-20°C