SP600125 | Enzo Life Sciences BML-EI305-0010 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

SP600125

catalog :

BML-EI305-0010

quantity :

10 mg

citations: 10

Reference
Oh Y, Yue P, Wang D, Tong J, Chen Z, Khuri F, et al. Suppression of death receptor 5 enhances cancer cell invasion and metastasis through activation of caspase-8/TRAF2-mediated signaling. Oncotarget. 2015;6:41324-38 pubmed publisher
Meng C, Liu G, Mu H, Zhou M, Zhang S, Xu Y. Amphiregulin may be a new biomarker of classically activated macrophages. Biochem Biophys Res Commun. 2015;466:393-9 pubmed publisher
Nemoto W, Ogata Y, Nakagawasai O, Yaoita F, Tadano T, Tan No K. Involvement of p38 MAPK activation mediated through AT1 receptors on spinal astrocytes and neurons in angiotensin II- and III-induced nociceptive behavior in mice. Neuropharmacology. 2015;99:221-31 pubmed publisher
Shi Q, Geldenhuys W, Sutariya V, Bishayee A, Patel I, Bhatia D. CArG-driven GADD45Î± activated by resveratrol inhibits lung cancer cells. Genes Cancer. 2015;6:220-30 pubmed
Huang W, Dai Y, Peng H, Kang C, Kuo C, Liou C. Phloretin ameliorates chemokines and ICAM-1 expression via blocking of the NF-ÎºB pathway in the TNF-Î±-induced HaCaT human keratinocytes. Int Immunopharmacol. 2015;27:32-7 pubmed publisher
Qi W, Niu J, Qin Q, Qiao Z, Gu Y. Glycated albumin triggers fibrosis and apoptosis via an NADPH oxidase/Nox4-MAPK pathway-dependent mechanism in renal proximal tubular cells. Mol Cell Endocrinol. 2015;405:74-83 pubmed publisher
Cao Z, Li X, Zou X, Greenwood M, Gerwick W, Murray T. Involvement of JNK and caspase activation in hoiamide A-induced neurotoxicity in neocortical neurons. Mar Drugs. 2015;13:903-19 pubmed publisher
Ji L, Zheng Z, Shi L, Huang Y, Lu B, Wang Z. Andrographolide decreased VEGFD expression in hepatoma cancer cells by inducing ubiquitin/proteasome-mediated cFos protein degradation. Biochim Biophys Acta. 2015;1850:750-8 pubmed publisher
Wu M, Xie X, Xu Z, Xie L, Chen Z, Shou L, et al. PP2A inhibitors suppress migration and growth of PANC-1 pancreatic cancer cells through inhibition on the Wnt/?-catenin pathway by phosphorylation and degradation of ?-catenin. Oncol Rep. 2014;32:513-22 pubmed publisher
Saxena M, Busca A, Pandey S, Kryworuchko M, Kumar A. CpG protects human monocytic cells against HIV-Vpr-induced apoptosis by cellular inhibitor of apoptosis-2 through the calcium-activated JNK pathway in a TLR9-independent manner. J Immunol. 2011;187:5865-78 pubmed publisher

product information

Product ID :

BML-EI305

Catalog Number :

BML-EI305-0010

Product Name :

SP600125

Product Type :

Biochemical

Size :

10 mg

list of Pubmed id :

26510914, 26365345, 26209257, 26124921, 25929446, 25681565, 25675001, 25596551, 24926961, 22068233

Product Description :

Potent, cell permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC50=40nM for JNK-1 and JNK-2 and 90nM for JNK-3). The inhibition is competitive with respect to ATP. Exhibits over 300-fold greater selectivity for JNK as compared to ERK1 and p38. Inhibits the phosphorylation of c-Jun and blocks the expression of IL-2, IFN-γ, TNF-α, and COX-2. Blocks IL-1-induced accumulation of phospho-Jun, induction of c-Jun transcription and anti CD3-induced apoptosis of CD4+ CD8+ thymocytes.

ALTnames :

Anthra(1,9-cd)pyrazol-6(2H)-one, 1,9-Pyrazoloanthrone

Purity :

≥98% (TLC)

Storage :

Ambient