GM-6001 | Enzo Life Sciences BML-EI300-0005 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

GM-6001

catalog :

BML-EI300-0005

quantity :

5 mg

citations: 11

Reference
Kikuchi K, Tatebe T, Sudo Y, Yokoyama M, Kidana K, Chiu Y, et al. GPR120 signaling controls amyloid-β degrading activity of matrix metalloproteinases. J Neurosci. 2021;: pubmed publisher
Nan L, Wei J, Jacko A, Culley M, Zhao J, Natarajan V, et al. Cross-talk between lysophosphatidic acid receptor 1 and tropomyosin receptor kinase A promotes lung epithelial cell migration. Biochim Biophys Acta. 2016;1863:229-35 pubmed publisher
Gioia M, Vindigni G, Testa B, Raniolo S, Fasciglione G, Coletta M, et al. Membrane Cholesterol Modulates LOX-1 Shedding in Endothelial Cells. PLoS ONE. 2015;10:e0141270 pubmed publisher
Chen S, Cao P, Dong N, Peng J, Zhang C, Wang H, et al. PCSK6-mediated corin activation is essential for normal blood pressure. Nat Med. 2015;21:1048-53 pubmed publisher
Hartmann M, Parra L, Ruschel A, Lindner C, Morrison H, Herrlich A, et al. Inside-out Regulation of Ectodomain Cleavage of Cluster-of-Differentiation-44 (CD44) and of Neuregulin-1 Requires Substrate Dimerization. J Biol Chem. 2015;290:17041-54 pubmed publisher
Moss M, Rasmussen F. Fluorescent substrates for the proteinases ADAM17, ADAM10, ADAM8, and ADAM12 useful for high-throughput inhibitor screening. Anal Biochem. 2007;366:144-8 pubmed
Kang T, Tschesche H, Amy Sang Q. Evidence for disulfide involvement in the regulation of intramolecular autolytic processing by human adamalysin19/ADAM19. Exp Cell Res. 2004;298:285-95 pubmed
Saghatelian A, Jessani N, Joseph A, Humphrey M, Cravatt B. Activity-based probes for the proteomic profiling of metalloproteases. Proc Natl Acad Sci U S A. 2004;101:10000-5 pubmed
Turk B, Wong T, Schwarzenbacher R, Jarrell E, Leppla S, Collier R, et al. The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor. Nat Struct Mol Biol. 2004;11:60-6 pubmed publisher
Ma D, Wu W, Yang G, Li J, Li J, Ye Q. Tetrahydroisoquinoline based sulfonamide hydroxamates as potent matrix metalloproteinase inhibitors. Bioorg Med Chem Lett. 2004;14:47-50 pubmed
Park H, Jin Y, Hurst D, Monroe C, Lee S, Schwartz M, et al. The intermediate S1' pocket of the endometase/matrilysin-2 active site revealed by enzyme inhibition kinetic studies, protein sequence analyses, and homology modeling. J Biol Chem. 2003;278:51646-53 pubmed

product information

Product ID :

BML-EI300

Catalog Number :

BML-EI300-0005

Product Name :

GM-6001

Product Type :

Biochemical

Size :

5 mg

list of Pubmed id :

26597701, 26495844, 26259032, 25925953, 17548045, 15242783, 15220480, 14718924, 14684295, 14532275

Product Description :

Potent broad-spectrum hydroxamate inhibitor of matrix metalloproteinases (MMPs). Ki values have been reported for the following human MMPs: MMP-1 (fibroblast collagenase): 0.4nM; MMP-2 (gelatinase A): 0.5nM; MMP-3 (stromelysin-1): 27nM; MMP-7 (matrilysin): 3.7nM; MMP-8 (neutrophil collagenase): 0.1nM; MMP-9 (gelatinase B): 0.2nM; MMP-12 (metalloelastase): 3.6nM; MMP-14 (MT1-MMP): 13.4nM; MMP-26 (endometase): 0.36nM. Also inhibits MMP-10, MMP-13, MMP-15, MMP-17, MMP-20, MMP-21, TACE, ADAM19, other ADAMs, anthrax lethal factor, neprilysin, leucine aminopeptidase, and DPPIII. Typical concentration range for use in tissue culture is 10-25µM. This inhibitor has also been used in vivo.

ALTnames :

Galardin, Ilomastat, N-[(2R)-2-(Hydroxamidocarbonylmethyl)-4-methylpentanoyl]-L-tryptophan methylamide

Purity :

≥98% (HPLC)

Buffer :

Lyophilized solid.

Storage :

-20°C