Radicicol | Enzo Life Sciences BML-EI285-0001 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

Radicicol

catalog :

BML-EI285-0001

quantity :

1 mg

citations: 10

Reference
Choi I, Lee Y, Park J, Song Y, Chang E, Kang S. Radicicol induces intracellular accumulation of glycan-deficient clusterin variant. Biochem Biophys Res Commun. 2015;458:555-560 pubmed publisher
Winssinger N, Barluenga S. Chemistry and biology of resorcylic acid lactones. Chem Commun (Camb). 2007;:22-36 pubmed
Connor J, McKenzie M, Parks G, Lyles D. Antiviral activity and RNA polymerase degradation following Hsp90 inhibition in a range of negative strand viruses. Virology. 2007;362:109-19 pubmed
Corbett K, Berger J. Structural basis for topoisomerase VI inhibition by the anti-Hsp90 drug radicicol. Nucleic Acids Res. 2006;34:4269-77 pubmed publisher
Hadden M, Lubbers D, Blagg B. Geldanamycin, radicicol, and chimeric inhibitors of the Hsp90 N-terminal ATP binding site. Curr Top Med Chem. 2006;6:1173-82 pubmed
Barker C, Hamlett J, Pennington S, Burrows F, Lundgren K, Lough R, et al. The topoisomerase II-Hsp90 complex: a new chemotherapeutic target?. Int J Cancer. 2006;118:2685-93 pubmed
Harashima K, Akimoto T, Nonaka T, Tsuzuki K, Mitsuhashi N, Nakano T. Heat shock protein 90 (Hsp90) chaperone complex inhibitor, radicicol, potentiated radiation-induced cell killing in a hormone-sensitive prostate cancer cell line through degradation of the androgen receptor. Int J Radiat Biol. 2005;81:63-76 pubmed
Gadelle D, Bocs C, Graille M, Forterre P. Inhibition of archaeal growth and DNA topoisomerase VI activities by the Hsp90 inhibitor radicicol. Nucleic Acids Res. 2005;33:2310-7 pubmed
Soga S, Shiotsu Y, Akinaga S, Sharma S. Development of radicicol analogues. Curr Cancer Drug Targets. 2003;3:359-69 pubmed
Hur E, Kim H, Choi S, Kim J, Yim S, Kwon H, et al. Reduction of hypoxia-induced transcription through the repression of hypoxia-inducible factor-1alpha/aryl hydrocarbon receptor nuclear translocator DNA binding by the 90-kDa heat-shock protein inhibitor radicicol. Mol Pharmacol. 2002;62:975-82 pubmed

product information

Product ID :

BML-EI285

Catalog Number :

BML-EI285-0001

Product Name :

Radicicol

Product Type :

Biochemical

Size :

1 mg

list of Pubmed id :

25680466, 17279252, 17258257, 16920739, 16842154, 16385570, 15962764, 15849317, 14529387, 12391259

Product Description :

Antifungal macrocyclic lactone antibiotic with antimalarial activity. Potent inhibitor of HSP90. Binds more strongly to HSP90 (nanomolar affinity) than to Grp94. Also binds to yeast HSP90, E. coli HtpG and TRAP-1. Non-competitive inhibitor of ATP citrate lyase. Anti-angiogenic. Specifically inhibits the interaction between HIF-1α/Arnt heterodimer and the hypoxia-responsive element (HRE), reducing VEGF expression. Protein tyrosine kinase inhibitor, e.g. p60v-src (IC50=0.27nM). Inhibitor of cyclooxygenase-2 (COX-2) expression (IC50=27nM) without affecting COX-1 expression in LPS-stimulated macrophages. Induces the differentiation of HL-60 cells into macrophages, blocking cell cycle at G1 and G2. Suppressor of NIH 3T3 cell transformation by diverse oncogenes such as mos, ras and src in part by blocking the key signal transduction intermediates such as MAP kinase and GAP-associated p62. Inhibitor of AP-1-, NF-κB- and serum response factor (SRF)-mediated transcription (e.g. expression of iNOS). Represses the transcriptional function of the estrogen receptor. Inhibits archeal growth and DNA topoisomerase VI (a Topo IIB family topoisomerase). Blocks replication of negative-strand RNA viruses.Causes morphological reversion of ras-transformed cells and leads to selective depletion of Raf kinase. Displays anti-angiogenic activity. Binds to and inhibits Hsp 90 molecular chaperone.

ALTnames :

Monorden, 1aS-(1aR*,2Z,4E,14*,15aR*)]-8-Chloro-1a,14,15,15a-tetrahydro-9,11-dihydroxy-14-methyl-6H-oxireno[e][2]benzoxacyclotetradecin-6,12(7H)-dione

Purity :

≥97% (HPLC)

Storage :

-20°C