Geldanamycin | Enzo Life Sciences BML-EI280-0001 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

Geldanamycin

catalog :

BML-EI280-0001

quantity :

1 mg

citations: 10

Reference
Zhang Z, Xie Z, Sun G, Yang P, Li J, Yang H, et al. Reversing drug resistance of cisplatin by hsp90 inhibitors in human ovarian cancer cells. Int J Clin Exp Med. 2015;8:6687-701 pubmed
Choi I, Lee Y, Park J, Song Y, Chang E, Kang S. Radicicol induces intracellular accumulation of glycan-deficient clusterin variant. Biochem Biophys Res Commun. 2015;458:555-560 pubmed publisher
Makondo K, Kamikawa A, Ahmed M, Terao A, Saito M, Kimura K. Geldanamycin enhances hepatocyte growth factor stimulation of eNOS phosphorylation in endothelial cells. Eur J Pharmacol. 2008;582:110-5 pubmed publisher
Sugimoto K, Sasaki M, Isobe Y, Tsutsui M, Suto H, Ando J, et al. Hsp90-inhibitor geldanamycin abrogates G2 arrest in p53-negative leukemia cell lines through the depletion of Chk1. Oncogene. 2008;27:3091-101 pubmed
Lesko E, Gozdzik J, Kijowski J, Jenner B, Wiecha O, Majka M. HSP90 antagonist, geldanamycin, inhibits proliferation, induces apoptosis and blocks migration of rhabdomyosarcoma cells in vitro and seeding into bone marrow in vivo. Anticancer Drugs. 2007;18:1173-81 pubmed
Wu W, Kao Y, Hu P, Chen J. Geldanamycin, a HSP90 inhibitor, attenuates the hypoxia-induced vascular endothelial growth factor expression in retinal pigment epithelium cells in vitro. Exp Eye Res. 2007;85:721-31 pubmed
Jeon Y, Park C, Kim K, Li Y, Kim J, Kim Y, et al. The heat-shock protein 90 inhibitor, geldanamycin, induces apoptotic cell death in Epstein-Barr virus-positive NK/T-cell lymphoma by Akt down-regulation. J Pathol. 2007;213:170-9 pubmed
Koga F, Tsutsumi S, Neckers L. Low dose geldanamycin inhibits hepatocyte growth factor and hypoxia-stimulated invasion of cancer cells. Cell Cycle. 2007;6:1393-402 pubmed
Ohta K, Okoshi R, Wakabayashi M, Ishikawa A, Sato Y, Kizaki H. Geldanamycin, a heat-shock protein 90-binding agent, induces thymocyte apoptosis through destabilization of Lck in presence of 12-O-tetradecanoylphorbol 13-acetate. Biomed Res. 2007;28:33-42 pubmed
Lang S, Klein D, Moser C, Gaumann A, Glockzin G, Dahlke M, et al. Inhibition of heat shock protein 90 impairs epidermal growth factor-mediated signaling in gastric cancer cells and reduces tumor growth and vascularization in vivo. Mol Cancer Ther. 2007;6:1123-32 pubmed

product information

Product ID :

BML-EI280

Catalog Number :

BML-EI280-0001

Product Name :

Geldanamycin

Product Type :

Biochemical

Size :

1 mg

list of Pubmed id :

26221207, 25680466, 18242595, 18071310, 17893518, 17870069, 17768706, 17525527, 17379955, 17363505

Product Description :

Potent antitumor antibiotic. Inhibitor of pp60src tyrosine kinase and of c-myc gene expression in murine lymphoblastoma cells. Inhibits the transforming activity of abl, erbB, fps, src, and yes. Binds specifically to heat shock protein 90 (HSP90) and to its endoplasmic reticulum homolog GP96 (GRP94). Capable of destabilizing several oncogene and proto-oncogene products. Potent inhibitor of the nuclear hormone receptor family. Protects against α-synuclein toxicity to dopaminergic neurons in Drosophila. Destabilizes mutant p53 protein from a number of breast, leukemic, and prostate cell lines. Inhibits basal and hypoxia-induced expression of c-Jun (IC50=75nM) and abolishes hypoxia-induced increase in c-Jun N-terminal kinase (JNK) activity. Inhibits telomerase activity through inhibition of HSP90, a chaperone required for the assembly and activation of telomerase in human cells. Hsp90 inhibitors geldanamycin or 17-DMAG reduces the uptake of Chaperone Mediated Autophagy (CMA) substrates by isolated lysosomes.~10-fold more potent than herbimycin A (Prod. No. BML-EI227)

Purity :

≥95% (HPLC)

Storage :

-20°C