KN-93 | Enzo Life Sciences BML-EI268-0001 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

KN-93

catalog :

BML-EI268-0001

quantity :

1 mg

citations: 4

Reference
Tombes R, Grant S, Westin E, Krystal G. G1 cell cycle arrest and apoptosis are induced in NIH 3T3 cells by KN-93, an inhibitor of CaMK-II (the multifunctional Ca2+/CaM kinase). Cell Growth Differ. 1995;6:1063-70 pubmed
Niki I, Okazaki K, Saitoh M, Niki A, Niki H, Tamagawa T, et al. Presence and possible involvement of Ca/calmodulin-dependent protein kinases in insulin release from the rat pancreatic beta cell. Biochem Biophys Res Commun. 1993;191:255-61 pubmed
Rasmussen G, Rasmussen C. Calmodulin-dependent protein kinase II is required for G1/S progression in HeLa cells. Biochem Cell Biol. 1995;73:201-7 pubmed
Sumi M, Kiuchi K, Ishikawa T, Ishii A, Hagiwara M, Nagatsu T, et al. The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells. Biochem Biophys Res Commun. 1991;181:968-75 pubmed

product information

Product ID :

BML-EI268

Catalog Number :

BML-EI268-0001

Product Name :

KN-93

Product Type :

Biochemical

Size :

1 mg

list of Pubmed id :

8519682, 8383489, 7576494, 1662507

Product Description :

KN-93 is a potent, selective and cell-permeable inhibitor of CaM kinase II (IC50=370 nM). Does not significantly inhibit PKA. Causes cell-cycle arrest in NIH 3T3 fibroblasts and HeLa cells. Inhibits glucose-induced and forskolin-stimulated insulin release from isolated pancreatic islets of Langerhans. Induces G1 cell cycle arrest and apoptosis in NIH 3T3 cells.

Purity :

≥95% (HPLC)

Storage :

-20°C