NS-398 | Enzo Life Sciences BML-EI261-0005 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

NS-398

catalog :

BML-EI261-0005

quantity :

5 mg

citations: 10

Reference
Bhattacharya I, DomÃnguez A, DrÃ¤gert K, Humar R, Haas E, Battegay E. Hypoxia potentiates tumor necrosis factor-Î± induced expression of inducible nitric oxide synthase and cyclooxygenase-2 in white and brown adipocytes. Biochem Biophys Res Commun. 2015;461:287-92 pubmed publisher
Zatelli M, Luchin A, Piccin D, Tagliati F, Bottoni A, Vignali C, et al. Cyclooxygenase-2 inhibitors reverse chemoresistance phenotype in medullary thyroid carcinoma by a permeability glycoprotein-mediated mechanism. J Clin Endocrinol Metab. 2005;90:5754-60 pubmed
Griswold D, Adams J. Constitutive cyclooxygenase (COX-1) and inducible cyclooxygenase (COX-2): rationale for selective inhibition and progress to date. Med Res Rev. 1996;16:181-206 pubmed
Futaki N, Yoshikawa K, Hamasaka Y, Arai I, Higuchi S, Iizuka H, et al. NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions. Gen Pharmacol. 1993;24:105-10 pubmed
Arai I, Hamasaka Y, Futaki N, Takahashi S, Yoshikawa K, Higuchi S, et al. Effect of NS-398, a new nonsteroidal anti-inflammatory agent, on gastric ulceration and acid secretion in rats. Res Commun Chem Pathol Pharmacol. 1993;81:259-70 pubmed
Masferrer J, Zweifel B, Manning P, Hauser S, Leahy K, Smith W, et al. Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic. Proc Natl Acad Sci U S A. 1994;91:3228-32 pubmed
Futaki N, Takahashi S, Yokoyama M, Arai I, Higuchi S, Otomo S. NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro. Prostaglandins. 1994;47:55-9 pubmed
Copeland R, Williams J, Giannaras J, Nurnberg S, Covington M, Pinto D, et al. Mechanism of selective inhibition of the inducible isoform of prostaglandin G/H synthase. Proc Natl Acad Sci U S A. 1994;91:11202-6 pubmed
Barnett J, Chow J, Ives D, Chiou M, Mackenzie R, Osen E, et al. Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system. Biochim Biophys Acta. 1994;1209:130-9 pubmed
Ouellet M, Percival M. Effect of inhibitor time-dependency on selectivity towards cyclooxygenase isoforms. Biochem J. 1995;306 ( Pt 1):247-51 pubmed

product information

Product ID :

BML-EI261

Catalog Number :

BML-EI261-0005

Product Name :

NS-398

Product Type :

Biochemical

Size :

5 mg

list of Pubmed id :

25881506, 16091477, 8656779, 8482483, 8235061, 8159730, 8140262, 7972034, 7947975, 7864817

Product Description :

Cyclooxygenase inhibitor. Selectively inhibits PGH synthase-2 (IC50=1 µM) with no inhibition of PGH synthase-1 at concentrations up to 100 µM. Protects neuronal cultures from LPS-induced neurotoxicity.

ALTnames :

N-[2-(Cyclohexyloxy)-4-nitrophenyl]-methanesulfonamide

Purity :

≥98% (HPLC)

Storage :

Ambient