This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
chemical
product name :
Chelerythrine chloride
catalog :
BML-EI225-0025
quantity :
25 mg
citations: 6
Reference
Zhang Y, Bhunia A, Wan K, Lee M, Chan S, Yu V, et al. Chelerythrine and sanguinarine dock at distinct sites on BclXL that are not the classic BH3 binding cleft. J Mol Biol. 2006;364:536-49 pubmed
Malikova J, Zdarilova A, Hlobilkova A, Ulrichova J. The effect of chelerythrine on cell growth, apoptosis, and cell cycle in human normal and cancer cells in comparison with sanguinarine. Cell Biol Toxicol. 2006;22:439-53 pubmed
Chan S, Lee M, Tan K, Yang L, Lee A, Flotow H, et al. Identification of chelerythrine as an inhibitor of BclXL function. J Biol Chem. 2003;278:20453-6 pubmed
Jarvis W, Turner A, Povirk L, Traylor R, Grant S. Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C. Cancer Res. 1994;54:1707-14 pubmed
Herbert J, Augereau J, Gleye J, Maffrand J. Chelerythrine is a potent and specific inhibitor of protein kinase C. Biochem Biophys Res Commun. 1990;172:993-9 pubmed
Ko F, Chen I, Wu S, Lee L, Haung T, Teng C. Antiplatelet effects of chelerythrine chloride isolated from Zanthoxylum simulans. Biochim Biophys Acta. 1990;1052:360-5 pubmed
product information
Product ID :
BML-EI225
Catalog Number :
BML-EI225-0025
Product Name :
Chelerythrine chloride
Product Type :
Biochemical
Size :
25 mg
list of Pubmed id :
17011577, 16964588, 12702731, 7511048, 2244923, 2162213
Product Description :
Reported to be a potent and selective inhibitor of protein kinase C (IC50=0.66µM). Although chelerythrine has numerous documented biological effects, studies have raised serious doubts about the effectiveness of chelerythrine as a PKC inhibitor.
Purity :
≥98% (HPLC, TLC)
Storage :
-20°C
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.