Auranofin | Enzo Life Sciences BML-EI206-0100 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

Auranofin

catalog :

BML-EI206-0100

quantity :

100 mg

citations: 12

Reference
Wolhuter K, Whitwell H, Switzer C, Burgoyne J, Timms J, Eaton P. Evidence against Stable Protein S-Nitrosylation as a Widespread Mechanism of Post-translational Regulation. Mol Cell. 2018;69:438-450.e5 pubmed publisher
Liao Y, Xia X, Liu N, Cai J, Guo Z, Li Y, et al. Growth arrest and apoptosis induction in androgen receptor-positive human breast cancer cells by inhibition of USP14-mediated androgen receptor deubiquitination. Oncogene. 2018;37:1896-1910 pubmed publisher
Yamada Y, Eto M, Ito Y, Mochizuki S, Son B, Ogawa S, et al. Suppressive Role of PPARÎ³-Regulated Endothelial Nitric Oxide Synthase in Adipocyte Lipolysis. PLoS ONE. 2015;10:e0136597 pubmed publisher
Hrabe J, O Leary B, Fath M, Rodman S, Button A, Domann F, et al. Disruption of thioredoxin metabolism enhances the toxicity of transforming growth factor β-activated kinase 1 (TAK1) inhibition in KRAS-mutated colon cancer cells. Redox Biol. 2015;5:319-327 pubmed publisher
MartÃnez GonzÃ¡lez J, Guevara Flores A, RendÃ³n J, Arenal I. Auranofin-induced oxidative stress causes redistribution of the glutathione pool in Taenia crassiceps cysticerci. Mol Biochem Parasitol. 2015;201:16-25 pubmed publisher
Bulman C, Bidlow C, Lustigman S, Cho Ngwa F, Williams D, Rascón A, et al. Repurposing auranofin as a lead candidate for treatment of lymphatic filariasis and onchocerciasis. PLoS Negl Trop Dis. 2015;9:e0003534 pubmed publisher
Drechsel D, Patel M. Respiration-dependent H2O2 removal in brain mitochondria via the thioredoxin/peroxiredoxin system. J Biol Chem. 2010;285:27850-8 pubmed publisher
Rigobello M, Scutari G, Boscolo R, Bindoli A. Induction of mitochondrial permeability transition by auranofin, a gold(I)-phosphine derivative. Br J Pharmacol. 2002;136:1162-8 pubmed
Corey E, Mehrotra M, Khan A. Antiarthritic gold compounds effectively quench electronically excited singlet oxygen. Science. 1987;236:68-9 pubmed
Betts W, Hurst N, Murphy G, Cleland L. Auranofin stimulates LTA hydrolase and inhibits 5-lipoxygenase/LTA synthase activity of isolated human neutrophils. Biochem Pharmacol. 1990;39:1233-7 pubmed
Columbo M, Galeone D, Guidi G, Kagey Sobotka A, Lichtenstein L, Pettit G, et al. Modulation of mediator release from human basophils and pulmonary mast cells and macrophages by auranofin. Biochem Pharmacol. 1990;39:285-91 pubmed
Rudkowski R, Ziegler J, Graham G, Champion G. Auranofin inhibits the activation pathways of polymorphonuclear leukocytes at multiple sites. Biochem Pharmacol. 1991;41:1921-9 pubmed

product information

Product ID :

BML-EI206

Catalog Number :

BML-EI206-0100

Product Name :

Auranofin

Product Type :

Biochemical

Size :

100 mg

list of Pubmed id :

26317347, 26114584, 26024834, 25700363, 20558743, 12163349, 3563489, 2157444, 2105731, 1645553

Product Description :

Gold derivative. Widely used as an anti-arthritic drug. Inhibits various leukocyte activation pathways at multiple sites. Inhibits release of inflammatory mediators from human basophils, pulmonary mast cells and macrophages. Also inhibits human neutrophil 5-lipoxygenase. Inhibits IκB kinase (IKK) by modifying Cys179 of the IKKß subunit. Efficient inducer of mitochondrial membrane permeability transition pore in the presence of calcium ions, potentially referable to its inhibition of mitochondrial thioredoxin reductase.

ALTnames :

SKF 39162, 1-Thio-β-D-glucopyranosatotriethyl phosphine gold-2,3,4,6-tetraacetate

Purity :

≥98% (HPLC)

Storage :

Ambient