Calphostin C | Enzo Life Sciences BML-EI198-0100 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

Calphostin C

catalog :

BML-EI198-0100

quantity :

100 µg

citations: 10

Reference
Xie P, Sun L, Oates P, Srivastava S, Kanwar Y. Pathobiology of renal-specific oxidoreductase/myo-inositol oxygenase in diabetic nephropathy: its implications in tubulointerstitial fibrosis. Am J Physiol Renal Physiol. 2010;298:F1393-404 pubmed publisher
Guo B, Hembruff S, Villeneuve D, Kirwan A, Parissenti A. Potent killing of paclitaxel- and doxorubicin-resistant breast cancer cells by calphostin C accompanied by cytoplasmic vacuolization. Breast Cancer Res Treat. 2003;82:125-41 pubmed
Sciorra V, Hammond S, Morris A. Potent direct inhibition of mammalian phospholipase D isoenzymes by calphostin-c. Biochemistry. 2001;40:2640-6 pubmed
Chen C, Tai H, Zhu D, Uckun F. Pharmacokinetic features and metabolism of calphostin C, a naturally occurring perylenequinone with antileukemic activity. Pharm Res. 1999;16:1003-9 pubmed
Hartzell H, Rinderknecht A. Calphostin C, a widely used protein kinase C inhibitor, directly and potently blocks L-type Ca channels. Am J Physiol. 1996;270:C1293-9 pubmed
Castagnino C, Yakisich J, Iacono R, BerrÃa M, Idoyaga Vargas V. Growth inhibition of herpes simplex virus-type 1 in calphostin C-treated astrocytes. Intervirology. 1995;38:332-8 pubmed
Svetlov S, Nigam S. Calphostin C, a specific protein kinase C inhibitor, activates human neutrophils: effect on phospholipase A2 and aggregation. Biochim Biophys Acta. 1993;1177:75-8 pubmed
Redman C, Lefevre J, MacDonald M. Inhibition of diacylglycerol kinase by the antitumor agent calphostin C. Evidence for similarity between the active site of diacylglycerol kinase and the regulatory site of protein kinase C. Biochem Pharmacol. 1995;50:235-41 pubmed
Jarvis W, Turner A, Povirk L, Traylor R, Grant S. Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C. Cancer Res. 1994;54:1707-14 pubmed
Iida T, Kobayashi E, Yoshida M, Sano H. Calphostins, novel and specific inhibitors of protein kinase C. II. Chemical structures. J Antibiot (Tokyo). 1989;42:1475-81 pubmed

product information

Product ID :

BML-EI198

Catalog Number :

BML-EI198-0100

Product Name :

Calphostin C

Product Type :

Biochemical

Size :

100 µg

list of Pubmed id :

20335317, 14692656, 11327888, 10450923, 8967428, 8880383, 7683494, 7632168, 7511048, 2478515

Product Description :

Potent and selective inhibitor of the protein kinase C (PKC). Inhibition is via interaction with the regulatory DAG binding site and phorbol ester binding site. Inhibition of PKC has been found to be light dependent. At higher concentrations inhibits myosin light chain kinase, cAMP-dependent protein kinase, protein kinase G, pp60v-src protein tyrosine kinase and DAG kinase. It also inhibits Phospholipase D1 and D2. Induces apoptotic DNA fragmentation and cell death. Kills breast cancer cells. Has antiviral potential. Inhibits cardiac L-type Ca2+ channels. Cell permeable. Inhibits cell proliferation of malignant glioma cells in light-treated conditions in vitro.

ALTnames :

UCN-1028C

Purity :

≥95% (HPLC)

Storage :

-20°C