Calyculin A | Enzo Life Sciences BML-EI192-0100 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

Calyculin A

catalog :

BML-EI192-0100

quantity :

100 µg

citations: 10

Reference
Tanaka H, Yoshida K, Okamura H, Morimoto H, Nagata T, Haneji T. Calyculin A induces apoptosis and stimulates phosphorylation of p65NF-kappaB in human osteoblastic osteosarcoma MG63 cells. Int J Oncol. 2007;31:389-96 pubmed
Tzivion G, Luo Z, Avruch J. Calyculin A-induced vimentin phosphorylation sequesters 14-3-3 and displaces other 14-3-3 partners in vivo. J Biol Chem. 2000;275:29772-8 pubmed
Fujiki H, Suganuma M. Unique features of the okadaic acid activity class of tumor promoters. J Cancer Res Clin Oncol. 1999;125:150-5 pubmed
Qiu W, Cobb R, Scholz W. Inhibition of p130cas tyrosine phosphorylation by calyculin A. J Leukoc Biol. 1998;63:631-5 pubmed
Favre B, Turowski P, Hemmings B. Differential inhibition and posttranslational modification of protein phosphatase 1 and 2A in MCF7 cells treated with calyculin-A, okadaic acid, and tautomycin. J Biol Chem. 1997;272:13856-63 pubmed
Song Q, Lavin M. Calyculin A, a potent inhibitor of phosphatases-1 and -2A, prevents apoptosis. Biochem Biophys Res Commun. 1993;190:47-55 pubmed
Murakami N, Sakai N, Nei K, Matsuyama S, Saito N, Tanaka C. Potassium and calcium channel involvement in induction of long-lasting synaptic enhancement by calyculin A, a protein phosphatase inhibitor, in rat hippocampal CA1 region. Neurosci Lett. 1994;176:181-4 pubmed
Takeuchi T, Nakajima M, Morimoto K. Calyculin A, a non-phorbol ester type tumor promotor, induced oxidative DNA damage in stimulated human neutrophil-like cells. Biochem Biophys Res Commun. 1994;205:1803-7 pubmed
Runnegar M, Maddatu T, DeLeve L, Berndt N, Govindarajan S. Differential toxicity of the protein phosphatase inhibitors microcystin and calyculin A. J Pharmacol Exp Ther. 1995;273:545-53 pubmed
Figurov A, Boddeke H, Muller D. Enhancement of AMPA-mediated synaptic transmission by the protein phosphatase inhibitor calyculin A in rat hippocampal slices. Eur J Neurosci. 1993;5:1035-41 pubmed

product information

Product ID :

BML-EI192

Catalog Number :

BML-EI192-0100

Product Name :

Calyculin A

Product Type :

Biochemical

Size :

100 µg

list of Pubmed id :

17611696, 10887173, 10235468, 9581808, 9153244, 8380694, 7830942, 7811268, 7714810, 7506616

Product Description :

Potent cell permeable inhibitor with high specificity for protein phosphatase 1 (PP1) and 2A (PP2A). Inhibits p130cas tyrosine phosphorylation. Enhances the phosphorylation level of NF-κB. Affects intracellular signalling processes that require 14-3-3. Potent non-phorbol type tumor promoter. Prevents γ-radiation induced apoptosis. Stimulates contraction of smooth muscle, induces intracellular protein phosphorylation in cultured human keratinocytes. Inhibits apoptosis. No effect on acid or alkaline phosphatases at 1µM. Treatment of MCF7 cells (breast cancer line), with 100nM, produced rapid (<20 min.) but incomplete inhibition of both PP1 (~60%) and PP2A (~70%).

Purity :

≥98% (HPLC)

Storage :

-20°C