Lavendustin A | Enzo Life Sciences BML-EI185-0005 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

Lavendustin A

catalog :

BML-EI185-0005

quantity :

5 mg

citations: 10

Reference
Löber K, Alfonso A, Escribano L, Botana L. Influence of the tyrosine kinase inhibitors STI571 (Glivec), lavendustin A and genistein on human mast cell line (HMC-1(560)) activation. J Cell Biochem. 2008;103:1076-88 pubmed
Taskinen P, Toth M, Vuolteenaho O, Magga J, Ruskoaho H. Inhibition of atrial wall stretch-induced cardiac hormone secretion by lavendustin A, a potent tyrosine kinase inhibitor. Endocrinology. 1999;140:4198-207 pubmed
Catarsi S, Ching S, Merz D, Drapeau P. Tyrosine phosphorylation during synapse formation between identified leech neurons. J Physiol. 1995;485 ( Pt 3):775-86 pubmed
Kornyei J, Li X, Lei Z, Rao C. Analysis of epidermal growth factor action in human myometrial smooth muscle cells. J Endocrinol. 1995;146:261-70 pubmed
Hu D, Fan T. Suppression of VEGF-induced angiogenesis by the protein tyrosine kinase inhibitor, lavendustin A. Br J Pharmacol. 1995;114:262-8 pubmed
Rodriguez J, Quignard J, Fagni L, Lafon Cazal M, Bockaert J. Blockade of nitric oxide synthesis by tyrosine kinase inhibitors in neurones. Neuropharmacology. 1994;33:1267-74 pubmed
Bishop J. Cellular oncogenes and retroviruses. Annu Rev Biochem. 1983;52:301-54 pubmed
Onoda T, Iinuma H, Sasaki Y, Hamada M, Isshiki K, Naganawa H, et al. Isolation of a novel tyrosine kinase inhibitor, lavendustin A, from Streptomyces griseolavendus. J Nat Prod. 1989;52:1252-7 pubmed
Hsu C, Persons P, Spada A, Bednar R, Levitzki A, Zilberstein A. Kinetic analysis of the inhibition of the epidermal growth factor receptor tyrosine kinase by Lavendustin-A and its analogue. J Biol Chem. 1991;266:21105-12 pubmed
O Dell T, Kandel E, Grant S. Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors. Nature. 1991;353:558-60 pubmed

product information

Product ID :

BML-EI185

Catalog Number :

BML-EI185-0005

Product Name :

Lavendustin A

Product Type :

Biochemical

Size :

5 mg

list of Pubmed id :

17661356, 10465292, 7562616, 7561638, 7533611, 7532813, 6351725, 2614420, 1939153, 1656271

Product Description :

Cell permeable tyrosine kinase inhibitor with little effect on cAMP-dependent protein kinase (PKA) or protein kinase C (PKC). Potent and selective inhibitor of the EGF receptor tyrosine kinase (IC50=11nM). Binds to a site on the kinase which is distinct from the ATP and peptide substrate binding sites. Inhibits EGF-induced proliferation of cultured human myometrial smooth muscle cells and suppresses VEGF-induced angiogenesis in rats. Effective at 10µM in cultured leech neurons. Also inhibits NMDA-stimulated cGMP production.

ALTnames :

5-Amino-[(N-2,5-dihydroxybenzyl)-N'-2-hydroxybenzyl]salicylic acid, RG14355

Purity :

≥95% (HPLC)

Storage :

-20°C