ML-9 | Enzo Life Sciences BML-EI153-0010 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

ML-9

catalog :

BML-EI153-0010

quantity :

10 mg

citations: 8

Reference
Smith U, Carvalho E, Mosialou E, Beguinot F, Formisano P, Rondinone C. PKB inhibition prevents the stimulatory effect of insulin on glucose transport and protein translocation but not the antilipolytic effect in rat adipocytes. Biochem Biophys Res Commun. 2000;268:315-20 pubmed
Reig J, Viniegra S, Ballesta J, Palmero M, Guitierrez L. Naphthalenesulfonamide derivatives ML9 and W7 inhibit catecholamine secretion in intact and permeabilized chromaffin cells. Neurochem Res. 1993;18:317-23 pubmed
Begum N. Stimulation of protein phosphatase-1 activity by insulin in rat adipocytes. Evaluation of the role of mitogen-activated protein kinase pathway. J Biol Chem. 1995;270:709-14 pubmed
Inoue G, Kuzuya H, Hayashi T, Yoshimasa Y, Kosaki A, Kono S, et al. Effects of ML-9 on insulin stimulation of glucose transport in 3T3-L1 adipocytes. J Biol Chem. 1993;268:5272-8 pubmed
Saitoh M, Naka M, Hidaka H. The modulatory role of myosin light chain phosphorylation in human platelet activation. Biochem Biophys Res Commun. 1986;140:280-7 pubmed
Nagatsu T, Suzuki H, Kiuchi K, Saitoh M, Hidaka H. Effects of myosin light-chain kinase inhibitor on catecholamine secretion from rat pheochromocytoma PC12h cells. Biochem Biophys Res Commun. 1987;143:1045-8 pubmed
Saitoh M, Ishikawa T, Matsushima S, Naka M, Hidaka H. Selective inhibition of catalytic activity of smooth muscle myosin light chain kinase. J Biol Chem. 1987;262:7796-801 pubmed
Seto M, Hidaka H, Sasaki Y. Effects of HA1077, a protein kinase inhibitor, on myosin phosphorylation and tension in smooth muscle. Eur J Pharmacol. 1991;195:267-72 pubmed

product information

Product ID :

BML-EI153

Catalog Number :

BML-EI153-0010

Product Name :

ML-9

Product Type :

Biochemical

Size :

10 mg

list of Pubmed id :

10679201, 8479600, 7822300, 7680348, 3778449, 3566753, 3108259, 1874276

Product Description :

Selective inhibitor of MLC kinase (Ki=3.8 µM). Inhibits insulin-stimulated 2-deoxyglucose transport and PP-1 activation in adipocytes, possibly via an effect on MAP kinase or its activation. Useful PKB inhibitor (IC50=10-50 µM). Also known to inhibit PKA (IC50=20 µM) and S6 kinase (IC50=50 µM). Does not inhibit PI 3-kinase.

ALTnames :

1-(5-Chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine . HCl

Purity :

≥98% (TLC)

Storage :

+4°C