K-252a | Enzo Life Sciences BML-EI152-0100 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

K-252a

catalog :

BML-EI152-0100

quantity :

100 µg

citations: 10

Reference
Nakajima S, Numakawa T, Adachi N, Ooshima Y, Odaka H, Yoshimura A, et al. Self-amplified BDNF transcription is a regulatory system for synaptic maturation in cultured cortical neurons. Neurochem Int. 2015;91:55-61 pubmed publisher
Lazarovici P, Rasouly D, Friedman L, Tabekman R, Ovadia H, Matsuda Y. K252a and staurosporine microbial alkaloid toxins as prototype of neurotropic drugs. Adv Exp Med Biol. 1996;391:367-77 pubmed
Glicksman M, Prantner J, Meyer S, Forbes M, Dasgupta M, Lewis M, et al. K-252a and staurosporine promote choline acetyltransferase activity in rat spinal cord cultures. J Neurochem. 1993;61:210-21 pubmed
Pawlowska Z, Hogan M, Kornecki E, Ehrlich Y. Ecto-protein kinase and surface protein phosphorylation in PC12 cells: interactions with nerve growth factor. J Neurochem. 1993;60:678-86 pubmed
Mizuno K, Saido T, Ohno S, Tamaoki T, Suzuki K. Staurosporine-related compounds, K252a and UCN-01, inhibit both cPKC and nPKC. FEBS Lett. 1993;330:114-6 pubmed
Glicksman M, Forbes M, Prantner J, Neff N. K-252a promotes survival and choline acetyltransferase activity in striatal and basal forebrain neuronal cultures. J Neurochem. 1995;64:1502-12 pubmed
Maroney A, Lipfert L, Forbes M, Glicksman M, Neff N, Siman R, et al. K-252a induces tyrosine phosphorylation of the focal adhesion kinase and neurite outgrowth in human neuroblastoma SH-SY5Y cells. J Neurochem. 1995;64:540-9 pubmed
Knight E, Connors T, Hudkins R, Maroney A, Neff N. Membranes of human neuroblastoma SH-SY5Y cells contain specific binding sites for [3H]K-252A. Biochem Biophys Res Commun. 1995;211:511-8 pubmed
Cheng B, Barger S, Mattson M. Staurosporine, K-252a, and K-252b stabilize calcium homeostasis and promote survival of CNS neurons in the absence of glucose. J Neurochem. 1994;62:1319-29 pubmed
Yasuzawa T, Iida T, Yoshida M, Hirayama N, Takahashi M, Shirahata K, et al. The structures of the novel protein kinase C inhibitors K-252a, b, c and d. J Antibiot (Tokyo). 1986;39:1072-8 pubmed

product information

Product ID :

BML-EI152

Catalog Number :

BML-EI152-0100

Product Name :

K-252a

Product Type :

Biochemical

Size :

100 µg

list of Pubmed id :

26596846, 8726076, 8515268, 8419543, 8365480, 7891076, 7830046, 7794263, 7510777, 3759659

Product Description :

Alkaloid isolated from soil fungi. General, cell permeable protein kinase inhibitor. Acts by binding to the ATP binding domain of the kinase. Potent inhibitor of Ca2+/calmodulin kinase II. Inhibits myosin light chain kinase, cAMP-dependent protein kinase (PKA), protein kinase C (PKC) (Ki=25nM), trk tyrosine kinase family members (gp140trk; IC50 =3nM) and cGMP-dependent protein kinase (PKG). Binds with high affinity to neuroblastoma membrane (2.7nM), promoting survival of primary neuronal cultures (75nM) and induction of neurite outgrowth in SH-SY5Y neuroblastoma cells along with phosphorylation of pp125 focal adhesion protein tyrosine kinase. Induces apoptosis.

Purity :

≥98% (HPLC)

Storage :

-20°C