H-7 | Enzo Life Sciences BML-EI148-0010 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

H-7

catalog :

BML-EI148-0010

quantity :

10 mg

citations: 10

Reference
Ku W, Cheng A, Wang T. Inhibition of telomerase activity by PKC inhibitors in human nasopharyngeal cancer cells in culture. Biochem Biophys Res Commun. 1997;241:730-6 pubmed
Engh R, Girod A, Kinzel V, Huber R, Bossemeyer D. Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity. J Biol Chem. 1996;271:26157-64 pubmed
Jarvis W, Turner A, Povirk L, Traylor R, Grant S. Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C. Cancer Res. 1994;54:1707-14 pubmed
Kawamoto S, Hidaka H. 1-(5-Isoquinolinesulfonyl)-2-methylpiperazine (H-7) is a selective inhibitor of protein kinase C in rabbit platelets. Biochem Biophys Res Commun. 1984;125:258-64 pubmed
Hidaka H, Inagaki M, Kawamoto S, Sasaki Y. Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C. Biochemistry. 1984;23:5036-41 pubmed
Schachtele C, Seifert R, Osswald H. Stimulus-dependent inhibition of platelet aggregation by the protein kinase C inhibitors polymyxin B, H-7 and staurosporine. Biochem Biophys Res Commun. 1988;151:542-7 pubmed
Takahashi I, Kobayashi E, Nakano H, Murakata C, Saitoh H, Suzuki K, et al. Potent selective inhibition of 7-O-methyl UCN-01 against protein kinase C. J Pharmacol Exp Ther. 1990;255:1218-21 pubmed
Boulis N, Davis M. Blockade of the spinal excitatory effect of cAMP on the startle reflex by intrathecal administration of the isoquinoline sulfonamide H-8: comparison to the protein kinase C inhibitor H-7. Brain Res. 1990;525:198-204 pubmed
Quick J, Ware J, Driedger P. The structure and biological activities of the widely used protein kinase inhibitor, H7, differ depending on the commercial source. Biochem Biophys Res Commun. 1992;187:657-63 pubmed
Gimond C, Aumailley M. Cellular interactions with the extracellular matrix are coupled to diverse transmembrane signaling pathways. Exp Cell Res. 1992;203:365-73 pubmed

product information

Product ID :

BML-EI148

Catalog Number :

BML-EI148-0010

Product Name :

H-7

Product Type :

Biochemical

Size :

10 mg

list of Pubmed id :

9434777, 8824261, 7511048, 6239622, 6238627, 2831891, 2262903, 2174710, 1530623, 1459201

Product Description :

Inhibits PKA (Ki=3.0μM), PKG (Ki=5.8μM), MLCK (Ki=97μM) and PKC (Ki=6μM). Also inhibits myosin light chain kinase. Induces apoptotic DNA fragmentation and cell death. Inhibits telomerase activity in treated NPC-076 cells. Cell permeable.

ALTnames :

(±)-1-(5-Isoquinolinesulfonyl)-2-methylpiperazine . 2HCl

Purity :

≥98% (TLC)

Storage :

+4°C