Gossypol | Enzo Life Sciences BML-EI130-0100 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

Gossypol

catalog :

BML-EI130-0100

quantity :

100 mg

citations: 10

Reference
Dodou K, Anderson R, Small D, Groundwater P. Investigations on gossypol: past and present developments. Expert Opin Investig Drugs. 2005;14:1419-34 pubmed
Konac E, Ekmekci A, Yurtcu E, Ergun M. An in vitro study of cytotoxic effects of gossypol on human epidermoid larynx carcinoma cell line (HEp-2). Exp Oncol. 2005;27:81-3 pubmed
Xu L, Yang D, Wang S, Tang W, Liu M, Davis M, et al. (-)-Gossypol enhances response to radiation therapy and results in tumor regression of human prostate cancer. Mol Cancer Ther. 2005;4:197-205 pubmed
Oliver C, Bauer J, Wolter K, Ubell M, Narayan A, O Connell K, et al. In vitro effects of the BH3 mimetic, (-)-gossypol, on head and neck squamous cell carcinoma cells. Clin Cancer Res. 2004;10:7757-63 pubmed
DeBonis S, Skoufias D, Lebeau L, Lopez R, Robin G, Margolis R, et al. In vitro screening for inhibitors of the human mitotic kinesin Eg5 with antimitotic and antitumor activities. Mol Cancer Ther. 2004;3:1079-90 pubmed
Jiang J, Sugimoto Y, Liu S, Chang H, Park K, Kulp S, et al. The inhibitory effects of gossypol on human prostate cancer cells-PC3 are associated with transforming growth factor beta1 (TGFbeta1) signal transduction pathway. Anticancer Res. 2004;24:91-100 pubmed
Mego M. Telomerase inhibitors in anticancer therapy: gossypol as a potential telomerase inhibitor. Bratisl Lek Listy. 2002;103:378-81 pubmed
Freedman T, Cao X, Oliveira R, Cass Q, Nafie L. Determination of the absolute configuration and solution conformation of gossypol by vibrational circular dichroism. Chirality. 2003;15:196-200 pubmed
Kuhn G, Cermak R, Minck K, Vujicic Z, Scharrer E. Gossypol induces chloride secretion in rat proximal colon. Eur J Pharmacol. 2002;457:187-94 pubmed
Le Blanc M, Russo J, Kudelka A, Smith J. An in vitro study of inhibitory activity of gossypol, a cottonseed extract, in human carcinoma cell lines. Pharmacol Res. 2002;46:551-5 pubmed

product information

Product ID :

BML-EI130

Catalog Number :

BML-EI130-0100

Product Name :

Gossypol

Product Type :

Biochemical

Size :

100 mg

list of Pubmed id :

16255680, 15812364, 15713891, 15570010, 15367702, 15015581, 12583508, 12520512, 12464365, 12457630

Product Description :

Mixture of ~65% (+)- and ~35% (-)-enantiomers. Male antifertility agent with antispermatogenic activity. Shows antitumor, antiviral and antioxidant actions. Small molecule inhibitor of Bcl-2/Bcl-XL. Induces apoptosis. Synergizes with radiation and chemotherapy in vitro. Reversible inhibitor of protein phosphatase 2B (PP2B; calcineurin). Protein kinase C (PKC) inhibitor. Inhibits activities of the mitotic kinesin Eg5 (IC50=10.8µM/L). Inhibits RBL-1, 5-lipoxygenase (IC50=0.3µM) and 12-lipoxygenase (IC50=0.7µM). Inhibits PAF and leukotriene-induced guinea pig parenchyma contractions. Novel direct-acting inhibitor of calcineurin.

ALTnames :

2,2’-bis[8-Formyl-1,6,7-trihydroxy-5-isopropyl-3-methylnaphthalene]

Purity :

≥90% (HPLC)

Storage :

-20°C