Dexamethasone | Enzo Life Sciences BML-EI126-0005 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

Dexamethasone

catalog :

BML-EI126-0005

quantity :

5 g

citations: 10

Reference
Zhang J, Garrison J, Poluektova L, Bronich T, Osna N. Liver-targeted antiviral peptide nanocomplexes as potential anti-HCV therapeutics. Biomaterials. 2015;70:37-47 pubmed publisher
Ehrhardt K, Guinn M, Quarton T, Zhang M, Bleris L. Reconfigurable hybrid interface for molecular marker diagnostics and in-situ reporting. Biosens Bioelectron. 2015;74:744-50 pubmed publisher
Grohmann U, Volpi C, Fallarino F, Bozza S, Bianchi R, Vacca C, et al. Reverse signaling through GITR ligand enables dexamethasone to activate IDO in allergy. Nat Med. 2007;13:579-86 pubmed
Schafer S, Wallerath T, Closs E, Schmidt C, Schwarz P, Forstermann U, et al. Dexamethasone suppresses eNOS and CAT-1 and induces oxidative stress in mouse resistance arterioles. Am J Physiol Heart Circ Physiol. 2005;288:H436-44 pubmed
Vital A, Goncalo M, Cruz M, Figueiredo A, Duarte C, Lopes M. Dexamethasone prevents granulocyte-macrophage colony-stimulating factor-induced nuclear factor-kappaB activation, inducible nitric oxide synthase expression and nitric oxide production in a skin dendritic cell line. Mediators Inflamm. 2003;12:71-8 pubmed
Shinoda J, McLaughlin K, Bell H, Swaroop G, Yamaguchi S, Holmes M, et al. Molecular mechanisms underlying dexamethasone inhibition of iNOS expression and activity in C6 glioma cells. Glia. 2003;42:68-76 pubmed
Korhonen R, Lahti A, Hamalainen M, Kankaanranta H, Moilanen E. Dexamethasone inhibits inducible nitric-oxide synthase expression and nitric oxide production by destabilizing mRNA in lipopolysaccharide-treated macrophages. Mol Pharmacol. 2002;62:698-704 pubmed
Matsumura M, Kakishita H, Suzuki M, Banba N, Hattori Y. Dexamethasone suppresses iNOS gene expression by inhibiting NF-kappaB in vascular smooth muscle cells. Life Sci. 2001;69:1067-77 pubmed
Reil T, Kashyap V, Sarkar R, Freishlag J, Gelabert H. Dexamethasone inhibits the phosphorylation of retinoblastoma protein in the suppression of human vascular smooth muscle cell proliferation. J Surg Res. 2000;92:108-13 pubmed
Gilardini Montani M, Tuosto L, Giliberti R, Stefanini L, Cundari E, Piccolella E. Dexamethasone induces apoptosis in human T cell clones expressing low levels of Bcl-2. Cell Death Differ. 1999;6:79-86 pubmed

product information

Product ID :

BML-EI126

Catalog Number :

BML-EI126-0005

Product Name :

Dexamethasone

Product Type :

Biochemical

Size :

5 g

list of Pubmed id :

26298393, 26210472, 17417651, 15598872, 12775356, 12594738, 12181447, 11508649, 10864490, 10200551

Product Description :

Anti-inflammatory glucocorticoid with anti-inflammatory activity. Induces the production of phospholipase A2 inhibitory protein (lipocortin). Inhibits induction of nitric oxide synthase (NOS) (IC50=5nM). Induces apoptosis in eosinophils, but inhibits it in neutrophils. Both effects are blocked by RU-486. Modulates osteogenesis of mesenchymal stem cells. Inhibits constitutive OPG mRNA steady-state levels in a dose- and time-dependent fashion, promoting osteoclast formation. Oral dexamethasone administration induces an increase in insulin resistance in humans. Furthermore, it inhibits differentiation of immature to mature dendritic cells.

ALTnames :

9α-Fluoro-16α-methylprednisolone

Purity :

≥98% (HPLC)

Storage :

Ambient