Baicalein | Enzo Life Sciences BML-EI106-0010 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

Baicalein

catalog :

BML-EI106-0010

quantity :

10 mg

citations: 10

Reference
Tarrago T, Kichik N, Claasen B, Prades R, Teixido M, Giralt E. Baicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitor. Bioorg Med Chem. 2008;16:7516-24 pubmed publisher
Cheng Y, He G, Mu X, Zhang T, Li X, Hu J, et al. Neuroprotective effect of baicalein against MPTP neurotoxicity: behavioral, biochemical and immunohistochemical profile. Neurosci Lett. 2008;441:16-20 pubmed publisher
Lin H, Shen S, Lin C, Yang L, Chen Y. Baicalein inhibition of hydrogen peroxide-induced apoptosis via ROS-dependent heme oxygenase 1 gene expression. Biochim Biophys Acta. 2007;1773:1073-86 pubmed
Deschamps J, Kenyon V, Holman T. Baicalein is a potent in vitro inhibitor against both reticulocyte 15-human and platelet 12-human lipoxygenases. Bioorg Med Chem. 2006;14:4295-301 pubmed
Lee H, Leung H, Lai M, Wu C. Baicalein induced cell cycle arrest and apoptosis in human lung squamous carcinoma CH27 cells. Anticancer Res. 2005;25:959-64 pubmed
Huang Y, Tsang S, Yao X, Chen Z. Biological properties of baicalein in cardiovascular system. Curr Drug Targets Cardiovasc Haematol Disord. 2005;5:177-84 pubmed
Shen Y, Chiou W, Chou Y, Chen C. Mechanisms in mediating the anti-inflammatory effects of baicalin and baicalein in human leukocytes. Eur J Pharmacol. 2003;465:171-81 pubmed
Hsu S, Hsieh Y, Hsieh W, Chou C. Baicalein induces a dual growth arrest by modulating multiple cell cycle regulatory molecules. Eur J Pharmacol. 2001;425:165-71 pubmed
Gao D, Tawa R, Masaki H, Okano Y, Sakurai H. Protective effects of baicalein against cell damage by reactive oxygen species. Chem Pharm Bull (Tokyo). 1998;46:1383-7 pubmed
Butenko I, Gladtchenko S, Galushko S. Anti-inflammatory properties and inhibition of leukotriene C4 biosynthesis in vitro by flavonoid baicalein from Scutellaria baicalensis georgy roots. Agents Actions. 1993;39 Spec No:C49-51 pubmed

product information

Product ID :

BML-EI106

Catalog Number :

BML-EI106-0010

Product Name :

Baicalein

Product Type :

Biochemical

Size :

10 mg

list of Pubmed id :

18650094, 18586394, 17532486, 16500106, 15868934, 15853750, 12650847, 11513834, 9775434, 8273583

Product Description :

Inhibits cellular Ca2+ uptake and calcium mobilization. Inhibitor of protein tyrosine kinase in leukemia (CEM) cells. Induces cell cycle arrest and apoptosis. Anti-inflammatory compound. Has anti-thrombotic, anti-proliferative and anti-mitogenic effects.Originally reported as a selective inhibitor of 12-lipoxygenase, baicalein has since been shown to inhibit both 12-LO and 15-LO (IC50=0.64µM for 12-LO and 1.6µM for 15-LO). Inhibits leukotriene biosynthesis (at higher concentrations) and release of lysosomal enzymes. Inhibits adjuvant-induced arthritis. Also inhibits prolyl oligopeptidase (POP/PREP)(IC50=36µM).

ALTnames :

5,6,7-Trihydroxyflavone

Purity :

≥98% (HPLC)

Storage :

-20°C