Thiolutin | Enzo Life Sciences BML-CT107-0005 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

Thiolutin

catalog :

BML-CT107-0005

quantity :

5 mg

citations: 8

Reference
Kebaara B, Nielsen L, Nickerson K, Atkin A. Determination of mRNA half-lives in Candida albicans using thiolutin as a transcription inhibitor. Genome. 2006;49:894-9 pubmed
Khachatourians G, Tipper D. In vivo effect of thiolutin on cell growth and macromolecular synthesis in Escherichia coli. Antimicrob Agents Chemother. 1974;6:304-10 pubmed
Grigull J, Mnaimneh S, Pootoolal J, Robinson M, Hughes T. Genome-wide analysis of mRNA stability using transcription inhibitors and microarrays reveals posttranscriptional control of ribosome biogenesis factors. Mol Cell Biol. 2004;24:5534-47 pubmed
Minamiguchi K, Kumagai H, Masuda T, Kawada M, Ishizuka M, Takeuchi T. Thiolutin, an inhibitor of HUVEC adhesion to vitronectin, reduces paxillin in HUVECs and suppresses tumor cell-induced angiogenesis. Int J Cancer. 2001;93:307-16 pubmed
Khachatourians G, Tipper D. Inhibition of messenger ribonucleic acid synthesis in Escherichia coli by thiolutin. J Bacteriol. 1974;119:795-804 pubmed
Tipper D. Inhibition of yeast ribonucleic acid polymerases by thiolutin. J Bacteriol. 1973;116:245-56 pubmed
Adams C, Gross D. The yeast heat shock response is induced by conversion of cells to spheroplasts and by potent transcriptional inhibitors. J Bacteriol. 1991;173:7429-35 pubmed
Elorza M, Lostau C, Villanueva J, Sentandreu R. Cell wall synthesis regulation in Saccharomyces cerevisiae. Effect of RNA and protein inhibition. Biochim Biophys Acta. 1976;454:263-72 pubmed

product information

Product ID :

BML-CT107

Catalog Number :

BML-CT107-0005

Product Name :

Thiolutin

Product Type :

Biochemical

Size :

5 mg

list of Pubmed id :

17036064, 15830477, 15169913, 11433393, 4604615, 4583213, 1938939, 793624

Product Description :

Sulfur containing antibiotic. Potent inhibitor of bacterial and yeast RNA polymerases. Inhibits mRNA chain elongation. Inhibits adhesion of endothelial cells (HUVECs) to vitronectin (IC50=0.83 µM) thereby inhibiting tumor cell-induced angiogenesis in vivo. Inhibits transcription in C. albicans. Inhibits microbiological growth in beer. Active against soil borne pathogens.

ALTnames :

6-(Acetamido)-4-methyl-1,2-dithiolo[4,3-b]-pyrrol-5(4H)-one

Purity :

≥95% (HPLC, TLC)

Storage :

-20°C