Fumagillin | Enzo Life Sciences BML-CT100-0001 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

Fumagillin

catalog :

BML-CT100-0001

quantity :

1 mg

citations: 10

Reference
Lefkove B, Govindarajan B, Arbiser J. Fumagillin: an anti-infective as a parent molecule for novel angiogenesis inhibitors. Expert Rev Anti Infect Ther. 2007;5:573-9 pubmed
Chen G, Weylie B, Hu C, Zhu J, Forough R. FGFR1/PI3K/AKT signaling pathway is a novel target for antiangiogenic effects of the cancer drug fumagillin (TNP-470). J Cell Biochem. 2007;101:1492-504 pubmed
Sheen I, Jeng K, Jeng W, Jeng C, Wang Y, Gu S, et al. Fumagillin treatment of hepatocellular carcinoma in rats: an in vivo study of antiangiogenesis. World J Gastroenterol. 2005;11:771-7 pubmed
McCOWEN M, Callender M, Lawlis J. Fumagillin (H-3), a new antibiotic with amebicidal properties. Science. 1951;113:202-3 pubmed
Gilbert M, Granath W. Whirling disease of salmonid fish: life cycle, biology, and disease. J Parasitol. 2003;89:658-67 pubmed
Molina J, Tourneur M, Sarfati C, Chevret S, de Gouvello A, Gobert J, et al. Fumagillin treatment of intestinal microsporidiosis. N Engl J Med. 2002;346:1963-9 pubmed
Griffith E, Su Z, Niwayama S, Ramsay C, Chang Y, Liu J. Molecular recognition of angiogenesis inhibitors fumagillin and ovalicin by methionine aminopeptidase 2. Proc Natl Acad Sci U S A. 1998;95:15183-8 pubmed
Lowther W, McMillen D, Orville A, Matthews B. The anti-angiogenic agent fumagillin covalently modifies a conserved active-site histidine in the Escherichia coli methionine aminopeptidase. Proc Natl Acad Sci U S A. 1998;95:12153-7 pubmed
Sin N, Meng L, Wang M, Wen J, Bornmann W, Crews C. The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2. Proc Natl Acad Sci U S A. 1997;94:6099-103 pubmed
Stepien H, Grochal M, Zielinski K, Mucha S, Kunert Radek J, Kulig A, et al. Inhibitory effects of fumagillin and its analogue TNP-470 on the function, morphology and angiogenesis of an oestrogen-induced prolactinoma in Fischer 344 rats. J Endocrinol. 1996;150:99-106 pubmed

product information

Product ID :

BML-CT100

Catalog Number :

BML-CT100-0001

Product Name :

Fumagillin

Product Type :

Biochemical

Size :

1 mg

list of Pubmed id :

17678422, 17295210, 15682466, 14809278, 14533670, 12075057, 9860943, 9770455, 9177176, 8708569

Product Description :

Inhibitor of angiogenesis and endothelial cell proliferation. Specific inhibitor of methionine aminopeptidase type II (MetAP-II) by covalently modifying a conserved active-site histidine. Precursor to TNP-470. Exhibits antitumor activity in estrogen-induced pituitary adenoma. Antineoplastic. Anti-infective.

ALTnames :

Fumidil B, Fumadil B, TNP-470

Purity :

≥95% (TLC)

Storage :

-20°C