Diphenyleneiodonium chloride | Enzo Life Sciences BML-CN240-0010 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

Diphenyleneiodonium chloride

catalog :

BML-CN240-0010

quantity :

10 mg

citations: 10

Reference
Scaife R. Selective and irreversible cell cycle inhibition by diphenyleneiodonium. Mol Cancer Ther. 2005;4:876-84 pubmed
Balcerczyk A, Soszyński M, Rybaczek D, Przygodzki T, Karowicz Bilinska A, Maszewski J, et al. Induction of apoptosis and modulation of production of reactive oxygen species in human endothelial cells by diphenyleneiodonium. Biochem Pharmacol. 2005;69:1263-73 pubmed
Scaife R. G2 cell cycle arrest, down-regulation of cyclin B, and induction of mitotic catastrophe by the flavoprotein inhibitor diphenyleneiodonium. Mol Cancer Ther. 2004;3:1229-37 pubmed
Morre D. Preferential inhibition of the plasma membrane NADH oxidase (NOX) activity by diphenyleneiodonium chloride with NADPH as donor. Antioxid Redox Signal. 2002;4:207-12 pubmed
Mendes A, Carvalho A, Caramona M, Lopes M. Diphenyleneiodonium inhibits NF-kappaB activation and iNOS expression induced by IL-1beta: involvement of reactive oxygen species. Mediators Inflamm. 2001;10:209-15 pubmed
Kono H, Rusyn I, Uesugi T, Yamashina S, Connor H, Dikalova A, et al. Diphenyleneiodonium sulfate, an NADPH oxidase inhibitor, prevents early alcohol-induced liver injury in the rat. Am J Physiol Gastrointest Liver Physiol. 2001;280:G1005-12 pubmed
Tew D. Inhibition of cytochrome P450 reductase by the diphenyliodonium cation. Kinetic analysis and covalent modifications. Biochemistry. 1993;32:10209-15 pubmed
Cross A, Jones O. The effect of the inhibitor diphenylene iodonium on the superoxide-generating system of neutrophils. Specific labelling of a component polypeptide of the oxidase. Biochem J. 1986;237:111-6 pubmed
Hancock J, Jones O. The inhibition by diphenyleneiodonium and its analogues of superoxide generation by macrophages. Biochem J. 1987;242:103-7 pubmed
Acker H, Dufau E, Huber J, Sylvester D. Indications to an NADPH oxidase as a possible pO2 sensor in the rat carotid body. FEBS Lett. 1989;256:75-8 pubmed

product information

Product ID :

BML-CN240

Catalog Number :

BML-CN240-0010

Product Name :

Diphenyleneiodonium chloride

Product Type :

Biochemical

Size :

10 mg

list of Pubmed id :

15956245, 15794948, 15486190, 11970854, 11577997, 11292610, 8399148, 3800872, 3036079, 2806553

Product Description :

Binds strongly to flavoproteins and is thus a powerful and specific inhibitor of several important enzymes, including nitric oxide synthase (NOS), NADPH-ubiquinone oxidoreductase, NADPH oxidases and NADPH cytochrome P450 oxidoreductase. Nitric oxide synthase, which shows significant homology with cytochrome P450 reductase, has been shown to be irreversibly inhibited by this compound in cultured peritoneal macrophages (IC50=30nM).

ALTnames :

DPI chloride, Dibenziodolium chloride

Purity :

≥98% (HPLC)

Storage :

-20°C