SQ 22536 | Enzo Life Sciences BML-CN140-0005 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

SQ 22536

catalog :

BML-CN140-0005

quantity :

5 mg

citations: 10

Reference
Ivonnet P, Salathe M, Conner G. Hydrogen peroxide stimulation of CFTR reveals an Epac-mediated, soluble AC-dependent cAMP amplification pathway common to GPCR signalling. Br J Pharmacol. 2015;172:173-84 pubmed publisher
Tamaoki J, Chiyotani A, Takeyama K, Yamauchi F, Tagaya E, Konno K. Relaxation and inhibition of contractile response to electrical field stimulation by Beraprost sodium in canine airway smooth muscle. Prostaglandins. 1993;45:363-73 pubmed
Talpain E, Armstrong R, Coleman R, Vardey C. Characterization of the PGE receptor subtype mediating inhibition of superoxide production in human neutrophils. Br J Pharmacol. 1995;114:1459-65 pubmed
Dixon D, Atwood H. Adenylate cyclase system is essential for long-term facilitation at the crayfish neuromuscular junction. J Neurosci. 1989;9:4246-52 pubmed
Goldsmith B, Abrams T. Reversal of synaptic depression by serotonin at Aplysia sensory neuron synapses involves activation of adenylyl cyclase. Proc Natl Acad Sci U S A. 1991;88:9021-5 pubmed
Lippe C, Ardizzone C. Actions of vasopressin and isoprenaline on the ionic transport across the isolated frog skin in the presence and the absence of adenyl cyclase inhibitors MDL12330A and SQ22536. Comp Biochem Physiol C. 1991;99:209-11 pubmed
Fabbri E, Brighenti L, Ottolenghi C. Inhibition of adenylate cyclase of catfish and rat hepatocyte membranes by 9-(tetrahydro-2-furyl)adenine (SQ 22536). J Enzyme Inhib. 1991;5:87-98 pubmed
Goldsmith B, Abrams T. cAMP modulates multiple K+ currents, increasing spike duration and excitability in Aplysia sensory neurons. Proc Natl Acad Sci U S A. 1992;89:11481-5 pubmed
Shi W, Bunney B. Roles of intracellular cAMP and protein kinase A in the actions of dopamine and neurotensin on midbrain dopamine neurons. J Neurosci. 1992;12:2433-8 pubmed
Harris D, Asaad M, Phillips M, Goldenberg H, Antonaccio M. Inhibition of adenylate cyclase in human blood platelets by 9-substituted adenine derivatives. J Cyclic Nucleotide Res. 1979;5:125-34 pubmed

product information

Product ID :

BML-CN140

Catalog Number :

BML-CN140-0005

Product Name :

SQ 22536

Product Type :

Biochemical

Size :

5 mg

list of Pubmed id :

25220136, 8388118, 7606349, 2480401, 1924365, 1711430, 1669444, 1333612, 1318960, 221552

Product Description :

SQ 22536 is a cell-permeable adenylate cyclase inhibitor. It inhibits cAMP production induced by prostaglandin E1 in platelet lysates (IC50=82 µM) and in intact platelets (IC50=1 µM). It has been successfully employed as a probe for the involvement of adenylate cyclase in a variety of receptor systems including those for prostaglandins and neurotransmitters. ReducesPGE2-induced inhibition of O2- production.

ALTnames :

9-THF-Ade

Purity :

≥99% (TLC)

Storage :

-20°C