This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
chemical
product name :
PK-11195
catalog :
BML-CM118-0025
quantity :
25 mg
citations: 6
Reference
Hirsch T, Decaudin D, Susin S, Marchetti P, Larochette N, Resche Rigon M, et al. PK11195, a ligand of the mitochondrial benzodiazepine receptor, facilitates the induction of apoptosis and reverses Bcl-2-mediated cytoprotection. Exp Cell Res. 1998;241:426-34 pubmed
Le Fur G, Vaucher N, Perrier M, Flamier A, Benavides J, Renault C, et al. Differentiation between two ligands for peripheral benzodiazepine binding sites, [3H]RO5-4864 and [3H]PK 11195, by thermodynamic studies. Life Sci. 1983;33:449-57 pubmed
Doble A, Ferris O, Burgevin M, Menager J, Uzan A, Dubroeucq M, et al. Photoaffinity labeling of peripheral-type benzodiazepine-binding sites. Mol Pharmacol. 1987;31:42-9 pubmed
Eshleman A, Murray T. Differential binding properties of the peripheral-type benzodiazepine ligands [3H]PK 11195 and [3H]Ro 5-4864 in trout and mouse brain membranes. J Neurochem. 1989;53:494-502 pubmed
Ferry A, Jaillon P, Lecocq B, Lecocq V, Jozefczak C. Pharmacokinetics and effects on exercise heart rate of PK 11195 (52028 RP), an antagonist of peripheral benzodiazepine receptors, in healthy volunteers. Fundam Clin Pharmacol. 1989;3:383-92 pubmed
Doble A, Benavides J, Ferris O, Bertrand P, Menager J, Vaucher N, et al. Dihydropyridine and peripheral type benzodiazepine binding sites: subcellular distribution and molecular size determination. Eur J Pharmacol. 1985;119:153-67 pubmed
product information
Product ID :
BML-CM118
Catalog Number :
BML-CM118-0025
Product Name :
PK-11195
Product Type :
Biochemical
Size :
25 mg
list of Pubmed id :
9637784, 6308375, 3027525, 2746235, 2553568, 2419140
Product Description :
PK-11195 is a ligand of the mitochondrial benzodiazepine receptor and selective antagonist of benzodiazepine. It facilitates the induction of apoptosis and reverses Bcl-2-mediated cytoprotection.
Purity :
≥98% (TLC)
Storage :
Ambient
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.