Bafilomycin A1 | Enzo Life Sciences BML-CM110-0100 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

Bafilomycin A1

catalog :

BML-CM110-0100

quantity :

100 µg

citations: 24

Reference
Ke P, Chang C, Hsiao Y. Baicalein Activates Parkin-Dependent Mitophagy through NDP52 and OPTN. Cells. 2022;11: pubmed publisher
Cattelani C, Lesiak D, Liebscher G, Singer I, Stasyk T, Wallnöfer M, et al. The SZT2 Interactome Unravels New Functions of the KICSTOR Complex. Cells. 2021;10: pubmed publisher
Santucci P, Greenwood D, Fearns A, Chen K, Jiang H, Gutierrez M. Intracellular localisation of Mycobacterium tuberculosis affects efficacy of the antibiotic pyrazinamide. Nat Commun. 2021;12:3816 pubmed publisher
El Manaa W, Duplan E, Goiran T, Lauritzen I, Vaillant Beuchot L, Lacas Gervais S, et al. Transcription- and phosphorylation-dependent control of a functional interplay between XBP1s and PINK1 governs mitophagy and potentially impacts Parkinson disease pathophysiology. Autophagy. 2021;:1-23 pubmed publisher
Tamargo Gómez I, Martínez García G, Suarez M, Rey V, Fueyo A, Codina Martínez H, et al. ATG4D is the main ATG8 delipidating enzyme in mammalian cells and protects against cerebellar neurodegeneration. Cell Death Differ. 2021;: pubmed publisher
Ryu H, Kim L, Jeong H, Yeo B, Lee J, Nam H, et al. GSK3B induces autophagy by phosphorylating ULK1. Exp Mol Med. 2021;53:369-383 pubmed publisher
Jung S, Choe S, Woo H, Jeong H, An H, Moon H, et al. Autophagic death of neural stem cells mediates chronic stress-induced decline of adult hippocampal neurogenesis and cognitive deficits. Autophagy. 2019;:1-19 pubmed publisher
Valverde D, Yu S, Boggavarapu V, Kumar N, Lees J, Walz T, et al. ATG2 transports lipids to promote autophagosome biogenesis. J Cell Biol. 2019;218:1787-1798 pubmed publisher
Haidar M, Asselbergh B, Adriaenssens E, de Winter V, Timmermans J, Auer Grumbach M, et al. Neuropathy-causing mutations in HSPB1 impair autophagy by disturbing the formation of SQSTM1/p62 bodies. Autophagy. 2019;15:1051-1068 pubmed publisher
Ebner P, Poetsch I, Deszcz L, Hoffmann T, Zuber J, Ikeda F. The IAP family member BRUCE regulates autophagosome-lysosome fusion. Nat Commun. 2018;9:599 pubmed publisher
Iseka F, Goetz B, Mushtaq I, An W, Cypher L, Bielecki T, et al. Role of the EHD Family of Endocytic Recycling Regulators for TCR Recycling and T Cell Function. J Immunol. 2018;200:483-499 pubmed publisher
Julian L, Delaney S, Wang Y, Goldberg A, Dore C, Yockell Lelièvre J, et al. Human Pluripotent Stem Cell-Derived TSC2-Haploinsufficient Smooth Muscle Cells Recapitulate Features of Lymphangioleiomyomatosis. Cancer Res. 2017;77:5491-5502 pubmed publisher
Hewitt G, Carroll B, Sarallah R, Correia Melo C, Ogrodnik M, Nelson G, et al. SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair. Autophagy. 2016;12:1917-1930 pubmed
SchlÃ¤fli A, Berezowska S, Adams O, Langer R, Tschan M. Reliable LC3 and p62 autophagy marker detection in formalin fixed paraffin embedded human tissue by immunohistochemistry. Eur J Histochem. 2015;59:2481 pubmed publisher
Katayama K, Kapoor K, Ohnuma S, Patel A, Swaim W, Ambudkar I, et al. Revealing the fate of cell surface human P-glycoprotein (ABCB1): The lysosomal degradation pathway. Biochim Biophys Acta. 2015;1853:2361-70 pubmed publisher
Petherick K, Conway O, Mpamhanga C, Osborne S, Kamal A, Saxty B, et al. Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy. J Biol Chem. 2015;290:11376-83 pubmed publisher
Aryal P, Kim K, Park P, Ham S, Cho J, Song K. Baicalein induces autophagic cell death through AMPK/ULK1 activation and downregulation of mTORC1 complex components in human cancer cells. FEBS J. 2014;281:4644-58 pubmed publisher
Brigger D, Torbett B, Chen J, Fey M, Tschan M. Inhibition of GATE-16 attenuates ATRA-induced neutrophil differentiation of APL cells and interferes with autophagosome formation. Biochem Biophys Res Commun. 2013;438:283-8 pubmed publisher
Bernhard S, Seidel K, Schmitz J, Klare S, Kirsch S, Schrezenmeier E, et al. The (pro)renin receptor ((P)RR) can act as a repressor of Wnt signalling. Biochem Pharmacol. 2012;84:1643-50 pubmed publisher
Okiyoneda T, Niibori A, Harada K, Kohno T, Hashimoto Y, Kusuhara H, et al. Bafilomycin A1-sensitive pathway is required for the maturation of cystic fibrosis transmembrane conductance regulator. Biochim Biophys Acta. 2006;1763:1017-23 pubmed
Shacka J, Klocke B, Roth K. Autophagy, bafilomycin and cell death: the "a-B-cs" of plecomacrolide-induced neuroprotection. Autophagy. 2006;2:228-30 pubmed
Jayadev S, Petranka J, Cheran S, Biermann J, Barrett J, Murphy E. Reduced capacitative calcium entry correlates with vesicle accumulation and apoptosis. J Biol Chem. 1999;274:8261-8 pubmed
Dröse S, Altendorf K. Bafilomycins and concanamycins as inhibitors of V-ATPases and P-ATPases. J Exp Biol. 1997;200:1-8 pubmed
Saurin A, Hamlett J, Clague M, Pennington S. Inhibition of mitogen-induced DNA synthesis by bafilomycin A1 in Swiss 3T3 fibroblasts. Biochem J. 1996;313 ( Pt 1):65-70 pubmed

product information

Product ID :

BML-CM110

Catalog Number :

BML-CM110-0100

Product Name :

Bafilomycin A1

Product Type :

Biochemical

Size :

100 µg

list of Pubmed id :

26150155, 26057472, 25833948, 23891751, 23022225, 17005267, 16874105, 10075732, 9023991, 8546711

Product Description :

Macrolide antibiotic that acts as a potent and selective inhibitor of vacuolar-type H+-ATPase (V-type) (IC50=004-0.4nmol/mg). Valuable tool for distinguishing among different types of ATPases. Inhibitor of endosomal acidification.¨Blocks lysosomal cholesterol trafficking in macrophages. Blocks pH regulation in brain cells.

Purity :

≥95% (HPLC, TLC)

Storage :

-20°C