This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
chemical
product name :
BAPTA-AM
catalog :
BML-CA411-0025
quantity :
25 mg
citations: 11
Reference
Freeman L, Guo H, David C, Brickey W, JHA S, Ting J. NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes. J Exp Med. 2017;214:1351-1370 pubmed publisher
Messner B, Türkcan A, Ploner C, Laufer G, Bernhard D. Cadmium overkill: autophagy, apoptosis and necrosis signalling in endothelial cells exposed to cadmium. Cell Mol Life Sci. 2016;73:1699-713 pubmed publisher
Breton C, Aubry D, Ginet V, Puyal J, Heulot M, Widmann C, et al. Combinative effects of β-Lapachone and APO866 on pancreatic cancer cell death through reactive oxygen species production and PARP-1 activation. Biochimie. 2015;116:141-53 pubmed publisher
Manganaro D, Consonni A, Guidetti G, Canobbio I, Visconte C, Kim S, et al. Activation of phosphatidylinositol 3-kinase β by the platelet collagen receptors integrin α2β1 and GPVI: The role of Pyk2 and c-Cbl. Biochim Biophys Acta. 2015;1853:1879-88 pubmed publisher
Bouschet T, Perez V, Fernandez C, Bockaert J, Eychene A, Journot L. Stimulation of the ERK pathway by GTP-loaded Rap1 requires the concomitant activation of Ras, protein kinase C, and protein kinase A in neuronal cells. J Biol Chem. 2003;278:4778-85 pubmed
Dieter P, Fitzke E, Duyster J. BAPTA induces a decrease of intracellular free calcium and a translocation and inactivation of protein kinase C in macrophages. Biol Chem Hoppe Seyler. 1993;374:171-4 pubmed
Yoshida A, Ueda T, Takauji R, Liu Y, Fukushima T, Inuzuka M, et al. Role of calcium ion in induction of apoptosis by etoposide in human leukemia HL-60 cells. Biochem Biophys Res Commun. 1993;196:927-34 pubmed
Billman G. Intracellular calcium chelator, BAPTA-AM, prevents cocaine-induced ventricular fibrillation. Am J Physiol. 1993;265:H1529-35 pubmed
Jiang S, Chow S, Nicotera P, Orrenius S. Intracellular Ca2+ signals activate apoptosis in thymocytes: studies using the Ca(2+)-ATPase inhibitor thapsigargin. Exp Cell Res. 1994;212:84-92 pubmed
Lew V, Tsien R, Miner C, Bookchin R. Physiological [Ca2+]i level and pump-leak turnover in intact red cells measured using an incorporated Ca chelator. Nature. 1982;298:478-81 pubmed
Harrison S, Bers D. The effect of temperature and ionic strength on the apparent Ca-affinity of EGTA and the analogous Ca-chelators BAPTA and dibromo-BAPTA. Biochim Biophys Acta. 1987;925:133-43 pubmed
product information
Product ID :
BML-CA411
Catalog Number :
BML-CA411-0025
Product Name :
BAPTA-AM
Product Type :
Biochemical
Size :
25 mg
list of Pubmed id :
26588916, 26188110, 25960397, 12473665, 8387795, 8240369, 8238564, 8174645, 6283392, 3113491
Product Description :
BAPTA is a Ca2+ chelator with 105-fold greater affinity for Ca2+ than for Mg2+. BAPTA-AM is a cell-permeable derivative which is widely used as an intracellular calcium sponge. Induces inactivation of protein kinase C. Also inhibits thapsigargin-induced apoptosis in rat thymocytes.
ALTnames :
1,2-bis-(o-Aminophenoxy)-ethane-N,N,N',N'-tetraacetic acid, tetraacetoxymethyl ester
Purity :
≥90% (HPLC)
Storage :
-20°C
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.