Calmidazolium chloride | Enzo Life Sciences BML-CA300-0010 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

Calmidazolium chloride

catalog :

BML-CA300-0010

quantity :

10 mg

citations: 10

Reference
Nachmany A, Gold V, Tsur A, Arad D, Weil M. Neural tube closure depends on nitric oxide synthase activity. J Neurochem. 2006;96:247-53 pubmed
Dedkova E, Ji X, Lipsius S, Blatter L. Mitochondrial calcium uptake stimulates nitric oxide production in mitochondria of bovine vascular endothelial cells. Am J Physiol Cell Physiol. 2004;286:C406-15 pubmed
Lacza Z, Puskar M, Figueroa J, Zhang J, Rajapakse N, Busija D. Mitochondrial nitric oxide synthase is constitutively active and is functionally upregulated in hypoxia. Free Radic Biol Med. 2001;31:1609-15 pubmed
Schaefer A, Magocsi M, Stocker U, Fandrich A, Marquardt H. Ca2+/calmodulin-dependent and -independent down-regulation of c-myb mRNA levels in erythropoietin-responsive murine erythroleukemia cells. The role of calcineurin. J Biol Chem. 1996;271:13484-90 pubmed
Wright L, Bertics P, Siegel F. Calmodulin N-methyltransferase. Kinetics, mechanism, and inhibitors. J Biol Chem. 1996;271:12737-43 pubmed
Hu J, El Fakahany E. The calmodulin antagonist calmidazolium stimulates release of nitric oxide in neuroblastoma N1E-115 cells. Neuroreport. 1993;4:198-200 pubmed
Murthy K, Makhlouf G. Vasoactive intestinal peptide/pituitary adenylate cyclase-activating peptide-dependent activation of membrane-bound NO synthase in smooth muscle mediated by pertussis toxin-sensitive Gi1-2. J Biol Chem. 1994;269:15977-80 pubmed
Gietzen K, Sadorf I, Bader H. A model for the regulation of the calmodulin-dependent enzymes erythrocyte Ca2+-transport ATPase and brain phosphodiesterase by activators and inhibitors. Biochem J. 1982;207:541-8 pubmed
Asano M. Divergent pharmacological effects of three calmodulin antagonists, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), chlorpromazine and calmidazolium, on isometric tension development and myosin light chain phosphorylation in intact bovine tr. J Pharmacol Exp Ther. 1989;251:764-73 pubmed
Schini V, Vanhoutte P. Inhibitors of calmodulin impair the constitutive but not the inducible nitric oxide synthase activity in the rat aorta. J Pharmacol Exp Ther. 1992;261:553-9 pubmed

product information

Product ID :

BML-CA300

Catalog Number :

BML-CA300-0010

Product Name :

Calmidazolium chloride

Product Type :

Biochemical

Size :

10 mg

list of Pubmed id :

16300634, 14512291, 11744335, 8662717, 8662690, 8384025, 7515875, 6299272, 2810127, 1374468

Product Description :

Binds reversibly to calmodulin, inhibiting calmodulin-mediated enzyme activation. It inhibits the Ca2+/calmodulin-induced activation of myosin light chain kinase in a concentration dependent manner (IC50=1 µM). Cell permeable. Inhibits calmodulin N-methyltransferase (Ki=65 nM). Blocks Ca2+-calmodulin binding to NOS. Inhibitor of voltage-gated Ca2+ channels

ALTnames :

R24571

Purity :

≥98% (HPLC)

Storage :

+4°C