Necrostatin-1 | Enzo Life Sciences BML-AP309-0020 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

Necrostatin-1

catalog :

BML-AP309-0020

quantity :

20 mg

citations: 12

Reference
Jung S, Choe S, Woo H, Jeong H, An H, Moon H, et al. Autophagic death of neural stem cells mediates chronic stress-induced decline of adult hippocampal neurogenesis and cognitive deficits. Autophagy. 2019;:1-19 pubmed publisher
Iurlaro R, Püschel F, León Annicchiarico C, O Connor H, Martin S, Palou Gramón D, et al. Glucose Deprivation Induces ATF4-Mediated Apoptosis through TRAIL Death Receptors. Mol Cell Biol. 2017;37: pubmed publisher
Oliver Metzig M, Fuchs D, Tagscherer K, GrÃ¶ne H, Schirmacher P, Roth W. Inhibition of caspases primes colon cancer cells for 5-fluorouracil-induced TNF-Î±-dependent necroptosis driven by RIP1 kinase and NF-ÎºB. Oncogene. 2016;35:3399-409 pubmed publisher
Selmi T, Alecci C, dell Aquila M, Montorsi L, Martello A, Guizzetti F, et al. ZFP36 stabilizes RIP1 via degradation of XIAP and cIAP2 thereby promoting ripoptosome assembly. BMC Cancer. 2015;15:357 pubmed publisher
Kitur K, Parker D, Nieto P, Ahn D, Cohen T, Chung S, et al. Toxin-induced necroptosis is a major mechanism of Staphylococcus aureus lung damage. PLoS Pathog. 2015;11:e1004820 pubmed publisher
Wu P, Zhu X, Jin W, Hao S, Liu Q, Zhang L. Oxaliplatin triggers necrosis as well as apoptosis in gastric cancer SGC-7901 cells. Biochem Biophys Res Commun. 2015;460:183-90 pubmed publisher
Moriwaki K, Bertin J, Gough P, Orlowski G, Chan F. Differential roles of RIPK1 and RIPK3 in TNF-induced necroptosis and chemotherapeutic agent-induced cell death. Cell Death Dis. 2015;6:e1636 pubmed publisher
Karl I, Jossberger Werner M, Schmidt N, Horn S, Goebeler M, Leverkus M, et al. TRAF2 inhibits TRAIL- and CD95L-induced apoptosis and necroptosis. Cell Death Dis. 2014;5:e1444 pubmed publisher
Kung G, Dai P, Deng L, Kitsis R. A novel role for the apoptosis inhibitor ARC in suppressing TNF?-induced regulated necrosis. Cell Death Differ. 2014;21:634-44 pubmed publisher
Fontanini A, Foti C, Potu H, Crivellato E, Maestro R, Bernardi P, et al. The Isopeptidase Inhibitor G5 Triggers a Caspase-independent Necrotic Death in Cells Resistant to Apoptosis: A COMPARATIVE STUDY WITH THE PROTEASOME INHIBITOR BORTEZOMIB. J Biol Chem. 2009;284:8369-81 pubmed publisher
Degterev A, Hitomi J, Germscheid M, Ch en I, Korkina O, Teng X, et al. Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat Chem Biol. 2008;4:313-21 pubmed publisher
Xu X, Chua C, Kong J, Kostrzewa R, Kumaraguru U, Hamdy R, et al. Necrostatin-1 protects against glutamate-induced glutathione depletion and caspase-independent cell death in HT-22 cells. J Neurochem. 2007;103:2004-14 pubmed

product information

Product ID :

BML-AP309

Catalog Number :

BML-AP309-0020

Product Name :

Necrostatin-1

Product Type :

Biochemical

Size :

20 mg

list of Pubmed id :

26522725, 25939870, 25880560, 25767076, 25675296, 25299769, 24440909, 19139105, 18408713, 17760869

Product Description :

Necrostatin-1 inhibits necroptosis, a non-apoptotic cell death pathway. Inhibits the loss of mitochondrial membrane potential in TNFα-treated Jurkat cells (EC50=490 nM). Does not inhibit FAS-induced apoptosis and has no effect on apoptotic morphology. It displays a pronounced protective effect in a mouse model of ischemic brain injury and inhibits myocardial cell death. Inhibits RIP1 kinase the key upstream kinase involved in the activation of necroptosis (EC50=180nM).

ALTnames :

Methylthiohydantoin-DL-tryptophan

Purity :

≥98% (TLC)

Storage :

Ambient