Gambogic acid | Enzo Life Sciences BML-AP305-0005 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

Gambogic acid

catalog :

BML-AP305-0005

quantity :

5 mg

citations: 3

Reference
Kasibhatla S, Jessen K, Maliartchouk S, Wang J, English N, Drewe J, et al. A role for transferrin receptor in triggering apoptosis when targeted with gambogic acid. Proc Natl Acad Sci U S A. 2005;102:12095-100 pubmed
Zhao L, Guo Q, You Q, Wu Z, Gu H. Gambogic acid induces apoptosis and regulates expressions of Bax and Bcl-2 protein in human gastric carcinoma MGC-803 cells. Biol Pharm Bull. 2004;27:998-1003 pubmed
Zhang H, Kasibhatla S, Wang Y, Herich J, Guastella J, Tseng B, et al. Discovery, characterization and SAR of gambogic acid as a potent apoptosis inducer by a HTS assay. Bioorg Med Chem. 2004;12:309-17 pubmed

product information

Product ID :

BML-AP305

Catalog Number :

BML-AP305-0005

Product Name :

Gambogic acid

Product Type :

Biochemical

Size :

5 mg

list of Pubmed id :

16103367, 15256729, 14723951

Product Description :

Gambogic Acid is a natural product isolated from Garcinia Hurburyi. It induces apoptosis in several tumor cell lines including T47D breast cancer cells and MGC-803 human gastric carcinoma cells but not in normal cells. Apoptosis induction proceeds via upregulation of bax and inhibition of bcl-2 expression.The target of gambogic acid has been identified as the transferrin receptor.

Purity :

≥95% (TLC)

Storage :

-20°C