Sulindac sulfide | Enzo Life Sciences BML-AP200-0025 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

Sulindac sulfide

catalog :

BML-AP200-0025

quantity :

25 mg

citations: 4

Reference
Yamamoto Y, Yin M, Lin K, Gaynor R. Sulindac inhibits activation of the NF-kappaB pathway. J Biol Chem. 1999;274:27307-14 pubmed
Herrmann C, Block C, Geisen C, Haas K, Weber C, Winde G, et al. Sulindac sulfide inhibits Ras signaling. Oncogene. 1998;17:1769-76 pubmed
Meade E, Smith W, DeWitt D. Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs. J Biol Chem. 1993;268:6610-4 pubmed
Piazza G, Rahm A, Krutzsch M, Sperl G, Paranka N, Gross P, et al. Antineoplastic drugs sulindac sulfide and sulfone inhibit cell growth by inducing apoptosis. Cancer Res. 1995;55:3110-6 pubmed

product information

Product ID :

BML-AP200

Catalog Number :

BML-AP200-0025

Product Name :

Sulindac sulfide

Product Type :

Biochemical

Size :

25 mg

list of Pubmed id :

10480951, 9778042, 8454631, 7606732

Product Description :

Active metabolite of sulindac (Prod. No. ALX-430-105). Inhibits cyclooxygenase. More selective for PGHS-1 (ID50=0.5 µM) over PGHS-2 (ID50=14 µM). Induces apoptosis by a cyclooxygenase-independent mechanism. Inhibits colorectal cancer growth and γ-secretase. NF-κB inhibitor. Inhibits Ras signaling.

ALTnames :

Z-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic acid

Purity :

≥99% (TLC)

Storage :

Ambient