Rapamycin | Enzo Life Sciences BML-A275-0025 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

Rapamycin

catalog :

BML-A275-0025

quantity :

25 mg

citations: 16

Reference
Rodriguez Laguna L, Agra N, Ibanez K, Oliva Molina G, Gordo G, Khurana N, et al. Somatic activating mutations in PIK3CA cause generalized lymphatic anomaly. J Exp Med. 2019;216:407-418 pubmed publisher
Wong P, Feng Y, Wang J, Shi R, Jiang X. Regulation of autophagy by coordinated action of mTORC1 and protein phosphatase 2A. Nat Commun. 2015;6:8048 pubmed publisher
Bae W, Choi J, Kim J, Jeong J. Cinnamic aldehyde suppresses hypoxia-induced angiogenesis via inhibition of hypoxia-inducible factor-1Î± expression during tumor progression. Biochem Pharmacol. 2015;98:41-50 pubmed publisher
Zhang P, Yu S, Li H, Liu C, Li J, Lin W, et al. ILT4 drives B7-H3 expression via PI3K/AKT/mTOR signalling and ILT4/B7-H3 co-expression correlates with poor prognosis in non-small cell lung cancer. FEBS Lett. 2015;589:2248-56 pubmed publisher
Hsu W, Chung H, Wu C, Wu H, Lee Y, Chen E, et al. Glutamate Stimulates Local Protein Synthesis in the Axons of Rat Cortical Neurons by Activating Î±-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors and Metabotropic Glutamate Receptors. J Biol Chem. 2015;290:20748-60 pubmed publisher
Zhou Z, Li X, He Z, Pan S, Yang Y, Zhang X, et al. Induction of apoptosis and autophagy via sirtuin1- and PI3K/Akt/mTOR-mediated pathways by plumbagin in human prostate cancer cells. Drug Des Devel Ther. 2015;9:1511-54 pubmed publisher
Jabir M, Hopkins L, Ritchie N, Ullah I, Bayes H, Li D, et al. Mitochondrial damage contributes to Pseudomonas aeruginosa activation of the inflammasome and is downregulated by autophagy. Autophagy. 2015;11:166-82 pubmed publisher
Winchell C, Graham J, Kurten R, Voth D. Coxiella burnetii type IV secretion-dependent recruitment of macrophage autophagosomes. Infect Immun. 2014;82:2229-38 pubmed publisher
Tedesco I, Russo M, Bilotto S, Spagnuolo C, Scognamiglio A, Palumbo R, et al. Dealcoholated red wine induces autophagic and apoptotic cell death in an osteosarcoma cell line. Food Chem Toxicol. 2013;60:377-84 pubmed publisher
Toulmay A, Prinz W. Direct imaging reveals stable, micrometer-scale lipid domains that segregate proteins in live cells. J Cell Biol. 2013;202:35-44 pubmed publisher
Su S, Zhou H, Xue M, Liu J, Ding L, Cao M, et al. Anti-tumor efficacy of a hepatocellular carcinoma vaccine based on dendritic cells combined with tumor-derived autophagosomes in murine models. Asian Pac J Cancer Prev. 2013;14:3109-16 pubmed
Lerner C, Bitto A, Pulliam D, Nacarelli T, Konigsberg M, Van Remmen H, et al. Reduced mammalian target of rapamycin activity facilitates mitochondrial retrograde signaling and increases life span in normal human fibroblasts. Aging Cell. 2013;12:966-77 pubmed publisher
Liu Y, Su Y, Wang J, Sun S, Wang T, Qiao X, et al. Rapamycin decreases tau phosphorylation at Ser214 through regulation of cAMP-dependent kinase. Neurochem Int. 2013;62:458-67 pubmed publisher
Facompre N, Sinha I, El Bayoumy K, Pinto J, Sinha R. Remarkable inhibition of mTOR signaling by the combination of rapamycin and 1,4-phenylenebis(methylene)selenocyanate in human prostate cancer cells. Int J Cancer. 2012;131:2134-42 pubmed publisher
Sanchez C, Ma C, Crowder R, Guintoli T, Phommaly C, Gao F, et al. Preclinical modeling of combined phosphatidylinositol-3-kinase inhibition with endocrine therapy for estrogen receptor-positive breast cancer. Breast Cancer Res. 2011;13:R21 pubmed publisher
Bitto A, Lerner C, Torres C, Roell M, Malaguti M, Perez V, et al. Long-term IGF-I exposure decreases autophagy and cell viability. PLoS ONE. 2010;5:e12592 pubmed publisher

product information

Product ID :

BML-A275

Catalog Number :

BML-A275-0025

Product Name :

Rapamycin

Product Type :

Biochemical

Size :

25 mg

list of Pubmed id :

26310906, 26297910, 26149216, 26134564, 25834399, 24643534, 23933363, 23836928, 23803088, 23795962

Product Description :

Macrocyclic-triene antibiotic possessing potent immunosuppressant activity. It forms a complex with FKBP12 that binds to an effector, thus inhibiting IL-2 and other growth promoting lymphokines. The effectors were identified as FRAP (FKBP12 rapamycin-associated protein) and RAFT1 (rapamycin and KFBP12 target). Rapamycin/FKBP complex does not inhibit FRAP PI 4-kinase activity, but does inhibit FRAP autophosphorylation. Rapamycin induces inhibition of p70s6k, p33cdk2 and p34cdc2. Selectively blocks signaling leading to the activation of p70/85 S6 kinase. Enhances apoptosis. Activator of autophagy both in vitro and in vivo.

ALTnames :

Sirolimus, AY-22,989, RAPA, Rapamune

Purity :

≥98% (HPLC)

Storage :

-20°C