Cyclosporin A | Enzo Life Sciences BML-A195-0100 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

Cyclosporin A

catalog :

BML-A195-0100

quantity :

100 mg

citations: 12

Reference
Zhu Y, Vidaurre O, Adula K, Kezunovic N, Wentling M, Huntley G, et al. Subcellular Distribution of HDAC1 in Neurotoxic Conditions Is Dependent on Serine Phosphorylation. J Neurosci. 2017;37:7547-7559 pubmed publisher
Bastian A, Thorpe J, Disch B, Bailey Downs L, Gangjee A, Devambatla R, et al. A small molecule with anticancer and antimetastatic activities induces rapid mitochondrial-associated necrosis in breast cancer. J Pharmacol Exp Ther. 2015;353:392-404 pubmed publisher
Clift D, Thorn R, Passarelli E, Kapoor M, LoPiccolo M, Richendrfer H, et al. Effects of embryonic cyclosporine exposures on brain development and behavior. Behav Brain Res. 2015;282:117-24 pubmed publisher
Bishop K, Coy H, Nerenz R, Meyer M, Pike J. Mouse Rankl expression is regulated in T cells by c-Fos through a cluster of distal regulatory enhancers designated the T cell control region. J Biol Chem. 2011;286:20880-91 pubmed publisher
Yoo Y, Jeung E. Melatonin suppresses cyclosporine A-induced autophagy in rat pituitary GH3 cells. J Pineal Res. 2010;48:204-11 pubmed publisher
Ferraccioli G, Tomietto P, De Santis M. Rationale for T cell inhibition by cyclosporin A in major autoimmune diseases. Ann N Y Acad Sci. 2005;1051:658-65 pubmed
Mascarell L, Truffa Bachi P. New aspects of cyclosporin a mode of action: from gene silencing to gene up-regulation. Mini Rev Med Chem. 2003;3:205-14 pubmed
Halestrap A, Connern C, Griffiths E, Kerr P. Cyclosporin A binding to mitochondrial cyclophilin inhibits the permeability transition pore and protects hearts from ischaemia/reperfusion injury. Mol Cell Biochem. 1997;174:167-72 pubmed
Yocum D. Immunological actions of cyclosporin A in rheumatoid arthritis. Br J Rheumatol. 1993;32 Suppl 1:38-41 pubmed
Kunz J, Hall M. Cyclosporin A, FK506 and rapamycin: more than just immunosuppression. Trends Biochem Sci. 1993;18:334-8 pubmed
Liu J. FK506 and ciclosporin: molecular probes for studying intracellular signal transduction. Trends Pharmacol Sci. 1993;14:182-8 pubmed
Calne R. Immunosuppression for organ grafting -- observations on cyclosporin A. Immunol Rev. 1979;46:113-24 pubmed

product information

Product ID :

BML-A195

Catalog Number :

BML-A195-0100

Product Name :

Cyclosporin A

Product Type :

Biochemical

Size :

100 mg

list of Pubmed id :

25720766, 25591474, 20136702, 16127006, 12570836, 9309682, 8448635, 7694398, 7692652, 383604

Product Description :

Cyclosporin A (CsA) is an immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection. CsA binds to cyclophilin and suppresses its proline rotamase activity. The CsA-cyclophilin complex inhibits calcineurin, a type 2B phosphatase. It is an important diagnostic tool for the characterization of permeability transition-related phenomena. It inhibits mitochondrial permeability transition pore opening however, pore inhibition becomes less efficient at increasing Ca2+ loads and inhibition is transient. Inhibits staurosporin-induced apoptosis in cultured neural cells and rotenone-induced apoptosis in PC-12 cells. Inhibits cytochrome c release from mitochondria. Inhibits nitric oxide (NO) synthesis.

ALTnames :

CsA

Purity :

≥98% (Assay)

Storage :

-20°C