Thyroid Peroxidase (human) monoclonal antibody (TPO 47) | Enzo Life Sciences ALX-BC-6010-S-L005 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

Thyroid Peroxidase (human) monoclonal antibody (TPO 47)

catalog :

ALX-BC-6010-S-L005

quantity :

5 ml

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

TPO 47

reactivity :

human

application :

western blot, immunohistochemistry

citations: 10

Reference
McDonald D, Pearce S. Thyroid peroxidase forms thionamide-sensitive homodimers: relevance for immunomodulation of thyroid autoimmunity. J Mol Med (Berl). 2009;87:971-80 pubmed publisher
Romei C, Ciampi R, Faviana P, Agate L, Molinaro E, Bottici V, et al. BRAFV600E mutation, but not RET/PTC rearrangements, is correlated with a lower expression of both thyroperoxidase and sodium iodide symporter genes in papillary thyroid cancer. Endocr Relat Cancer. 2008;15:511-20 pubmed publisher
Gharib H. Current evaluation of thyroid nodules. Trends Endocrinol Metab. 1994;5:365-9 pubmed
Landriscina M, Fabiano A, Altamura S, Bagala C, Piscazzi A, Cassano A, et al. Reverse transcriptase inhibitors down-regulate cell proliferation in vitro and in vivo and restore thyrotropin signaling and iodine uptake in human thyroid anaplastic carcinoma. J Clin Endocrinol Metab. 2005;90:5663-71 pubmed
Caraccio N, Giannini R, Cuccato S, Faviana P, Berti P, Galleri D, et al. Type I interferons modulate the expression of thyroid peroxidase, sodium/iodide symporter, and thyroglobulin genes in primary human thyrocyte cultures. J Clin Endocrinol Metab. 2005;90:1156-62 pubmed
Estienne V, Blanchet C, Niccoli Sire P, Duthoit C, Durand Gorde J, Geourjon C, et al. Molecular model, calcium sensitivity, and disease specificity of a conformational thyroperoxidase B-cell epitope. J Biol Chem. 1999;274:35313-7 pubmed
Estienne V, Duthoit C, Vinet L, Durand Gorde J, Carayon P, Ruf J. A conformational B-cell epitope on the C-terminal end of the extracellular part of human thyroid peroxidase. J Biol Chem. 1998;273:8056-62 pubmed
De Micco C, Vasko V, Garcia S, Zoro P, Denizot A, Henry J. Fine-needle aspiration of thyroid follicular neoplasm: diagnostic use of thyroid peroxidase immunocytochemistry with monoclonal antibody 47. Surgery. 1994;116:1031-5 pubmed
De Micco C, Zoro P, Garcia S, Skoog L, Tani E, Carayon P, et al. Thyroid peroxidase immunodetection as a tool to assist diagnosis of thyroid nodules on fine-needle aspiration biopsy. Eur J Endocrinol. 1994;131:474-9 pubmed
De Micco C, Zoro P, Henry J. [Malignancy markers in the cytodiagnosis of thyroid nodules. Thyroid peroxidase]. Ann Pathol. 1994;14:378-83 pubmed

product information

Product ID :

ALX-BC-6010-S

Catalog Number :

ALX-BC-6010-S-L005

Product Name :

Thyroid Peroxidase (human) monoclonal antibody (TPO 47)

Host species :

Mouse

Clonality :

Monoclonal

Product Type :

Antibody

Size :

5 ml

list of Pubmed id :

19669106, 18509003, 18407231, 16030158, 15562032, 10585396, 9525906, 7985083, 7952158, 7857412

Clone :

TPO 47

Isotype :

IgG1

SPECIES REACTIVITY :

Human

ALTnames :

TPO

Immunogen :

Human TPO (thyroid peroxidase).

Specificity :

Recognizes a linear epitope (aa 713-721) on human TPO protein.

Buffer :

Sterile supernatant. 0.6 - 0.9g/ml. Contains 0.1% sodium azide.

Uses :

Assists immunocytological diagnosis of malignancy on fine needle aspirates (FNA) of thyroid nodules. Strongly stains human TPO in normal thyroid tissues but does not recognize tumoral human TPO.

Application Summary :

IHC (PS), WB

Storage :

+4°C