This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
ELISA/assay
product name :
Osteoprotegerin (human) ELISA kit
catalog :
ALX-850-280A-KI01
quantity :
96 wells
citations: 3
Reference
Secchiero P, Corallini F, Rimondi E, Chiaruttini C, di Iasio M, Rustighi A, et al. Activation of the p53 pathway down-regulates the osteoprotegerin expression and release by vascular endothelial cells. Blood. 2008;111:1287-94 pubmed
Zauli G, Corallini F, Bossi F, Fischetti F, Durigutto P, Celeghini C, et al. Osteoprotegerin increases leukocyte adhesion to endothelial cells both in vitro and in vivo. Blood. 2007;110:536-43 pubmed
Secchiero P, Corallini F, Pandolfi A, Consoli A, Candido R, Fabris B, et al. An increased osteoprotegerin serum release characterizes the early onset of diabetes mellitus and may contribute to endothelial cell dysfunction. Am J Pathol. 2006;169:2236-44 pubmed
product information
Product ID :
ALX-850-280A
Catalog Number :
ALX-850-280A-KI01
Product Name :
Osteoprotegerin (human) ELISA kit
Product Type :
Kit
Size :
96 wells
list of Pubmed id :
18000166, 17363729, 17148684
Product Description :
The Osteoprotegerin (human) ELISA kit is a complete, colorimetric, immunometric immunoassay kit for the quantitative determination of osteoprotegerin in plasma and serum with results in just ~5 hours.
SPECIES REACTIVITY :
Human
Background :
Osteoprotegerin (OPG) or osteoclast inhibitory factor (OCIF) is a glycoprotein of the TNF receptor superfamily 11b (gene name TNFRSF11B). OPG is synthesized as a monomer of 380 amino acids and is assembled as a homodimer within the cell, and then secreted mainly as a disulfide-linked homodimer into the extracellular compartment. OPG is produced by many different tissues and cell types including osteoblasts. OPG is a negative regulator of bone resorption by acting as decoy receptor for RANKL, thus neutralizing its function in osteoclastogenesis. This glycoprotein is also involved in the regulation of vascular calcification.
ALTnames :
OPG, TNFRSF 11B, Tumor Necrosis Factor receptor superfamily member 11B, Osteoclastogenesis Inhibitory Factor, OCIF
Uses :
For the quantitative determination of human osteoprotegerin in serum and plasma.
Application Summary :
ELISA, Colorimetric detection
Storage :
+4°C
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.