MHC Class I monoclonal antibody (W6/32) (R-PE conjugate) | Enzo Life Sciences ALX-805-711R-C100 product information

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product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

MHC Class I monoclonal antibody (W6/32) (R-PE conjugate)

catalog :

ALX-805-711R-C100

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

clone name :

W6/32

reactivity :

human

application :

flow cytometry

citations: 10

Reference
Le Discorde M, Moreau P, Sabatier P, Legeais J, Carosella E. Expression of HLA-G in human cornea, an immune-privileged tissue. Hum Immunol. 2003;64:1039-44 pubmed
Dangoria N, DeLay M, Kingsbury D, Mear J, Uchanska Ziegler B, Ziegler A, et al. HLA-B27 misfolding is associated with aberrant intermolecular disulfide bond formation (dimerization) in the endoplasmic reticulum. J Biol Chem. 2002;277:23459-68 pubmed
Tran T, Ivanyi P, Hilgert I, Brdicka T, Pla M, Breur B, et al. The epitope recognized by pan-HLA class I-reactive monoclonal antibody W6/32 and its relationship to unusual stability of the HLA-B27/beta2-microglobulin complex. Immunogenetics. 2001;53:440-6 pubmed
Ladasky J, Shum B, Canavez F, Seuanez H, Parham P. Residue 3 of beta2-microglobulin affects binding of class I MHC molecules by the W6/32 antibody. Immunogenetics. 1999;49:312-20 pubmed
Shields M, Ribaudo R. Mapping of the monoclonal antibody W6/32: sensitivity to the amino terminus of beta2-microglobulin. Tissue Antigens. 1998;51:567-70 pubmed
Hao W, Gladstone P, Engardt S, Greenbaum C, Palmer J. Major histocompatibility complex class I molecule expression is normal on peripheral blood lymphocytes from patients with insulin-dependent diabetes mellitus. J Clin Invest. 1996;98:1613-8 pubmed
Jacobsen C, Aasted B, Broe M, Petersen J. Reactivities of 20 anti-human monoclonal antibodies with leucocytes from ten different animal species. Vet Immunol Immunopathol. 1993;39:461-6 pubmed
Goodfellow P, Banting G, Wiles M, Tunnacliffe A, Parkar M, Solomon E, et al. The gene, MIC4, which controls expression of the antigen defined by monoclonal antibody F10.44.2, is on human chromosome 11. Eur J Immunol. 1982;12:659-63 pubmed
Tunnacliffe A, Goodfellow P, Banting G, Solomon E, Knowles B, Andrews P. Human chromosome 11 carries at least four genes controlling expression of cell-surface antigens. Somatic Cell Genet. 1983;9:629-42 pubmed
Brodsky F, Parham P. Evolution of HLA antigenic determinants: species cross-reactions of monoclonal antibodies. Immunogenetics. 1982;15:151-66 pubmed

product information

Product ID :

ALX-805-711R

Catalog Number :

ALX-805-711R-C100

Product Name :

MHC Class I monoclonal antibody (W6/32) (R-PE conjugate)

Host species :

Mouse

Clonality :

Monoclonal

Conjugation :

R-PE

Product Type :

Antibody

Size :

100 µg

list of Pubmed id :

14602233, 11978783, 11685454, 10079295, 9672158, 8833910, 8116221, 7140811, 6623314, 6174442

Clone :

W6/32

Isotype :

IgG2a

SPECIES REACTIVITY :

Human, Monkey, Cat, Bovine

Background :

HLA-class I major histocompatibility (MHC) antigens are intrinsic membrane glycoproteins expressed on nucleated cells and noncovalently associated with an invariant beta2 microglobulin. They carry foreign determinants important for immune recognition by cytotoxic T cells, thus important for anti-viral and anti-tumour defence. Human HLA-class I antigens are represented by HLA-A, HLA-B and HLA-C molecules.

ALTnames :

HLA Class I

Immunogen :

Membrane of human tonsil cells.

Specificity :

Recognizes virtually all nucleated human cells. Suitable as positive control for HLA tissue typing and crossmatching.

Buffer :

Liquid. In PBS containing 15mM sodium azide and 0.2% BSA.

Application Summary :

Storage :

+4°C