pan-CEACAM (1,3,4,5,6) (human) monoclonal antibody (D14HD11) | Enzo Life Sciences ALX-805-080-C100 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

pan-CEACAM (1,3,4,5,6) (human) monoclonal antibody (D14HD11)

catalog :

ALX-805-080-C100

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

D14HD11

The same clone is also sold as:

Invitrogen: MA1-17761
Abcam: ab4567

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, flow cytometry

citations: 10

Reference
Baczynska D, Wietrzyk J, Madej J, Krop Watorek A, Dabrowska A, Widerak K, et al. The tumorigenic potential of human CX-1 colon adenocarcinoma cells depends on carcinoembryonic antigen (CEACAM5) expression. Cell Mol Biol Lett. 2003;8:471-86 pubmed
Boulton I, Gray Owen S. Neisserial binding to CEACAM1 arrests the activation and proliferation of CD4+ T lymphocytes. Nat Immunol. 2002;3:229-36 pubmed
Billker O, Popp A, Brinkmann V, Wenig G, Schneider J, Caron E, et al. Distinct mechanisms of internalization of Neisseria gonorrhoeae by members of the CEACAM receptor family involving Rac1- and Cdc42-dependent and -independent pathways. EMBO J. 2002;21:560-71 pubmed
Watt S, Teixeira A, Zhou G, Doyonnas R, Zhang Y, Grunert F, et al. Homophilic adhesion of human CEACAM1 involves N-terminal domain interactions: structural analysis of the binding site. Blood. 2001;98:1469-79 pubmed
Muenzner P, Naumann M, Meyer T, Gray Owen S. Pathogenic Neisseria trigger expression of their carcinoembryonic antigen-related cellular adhesion molecule 1 (CEACAM1; previously CD66a) receptor on primary endothelial cells by activating the immediate early response transcription factor, nuclear . J Biol Chem. 2001;276:24331-40 pubmed
Popp A, Dehio C, Grunert F, Meyer T, Gray Owen S. Molecular analysis of neisserial Opa protein interactions with the CEA family of receptors: identification of determinants contributing to the differential specificities of binding. Cell Microbiol. 1999;1:169-81 pubmed
Muenzner P, Dehio C, Fujiwara T, Achtman M, Meyer T, Gray Owen S. Carcinoembryonic antigen family receptor specificity of Neisseria meningitidis Opa variants influences adherence to and invasion of proinflammatory cytokine-activated endothelial cells. Infect Immun. 2000;68:3601-7 pubmed
Guignot J, Peiffer I, Bernet Camard M, Lublin D, Carnoy C, Moseley S, et al. Recruitment of CD55 and CD66e brush border-associated glycosylphosphatidylinositol-anchored proteins by members of the Afa/Dr diffusely adhering family of Escherichia coli that infect the human polarized intestinal Caco-2/TC7 cells. Infect Immun. 2000;68:3554-63 pubmed
Krop Watorek A, Laskowska A, Salwa J, Kłopocki A, Grunert F, Ugorski M. CEA-related proteins on human urothelial cell lines of different transformation grades. Cancer Lett. 1999;139:15-22 pubmed
Gray Owen S, Dehio C, Haude A, Grunert F, Meyer T. CD66 carcinoembryonic antigens mediate interactions between Opa-expressing Neisseria gonorrhoeae and human polymorphonuclear phagocytes. EMBO J. 1997;16:3435-45 pubmed

product information

Product ID :

ALX-805-080

Catalog Number :

ALX-805-080-C100

Product Name :

pan-CEACAM (1,3,4,5,6) (human) monoclonal antibody (D14HD11)

Host species :

Mouse

Clonality :

Monoclonal

Product Type :

Antibody

Size :

100 µg

list of Pubmed id :

12813580, 11850628, 11847104, 11520797, 11306560, 11207550, 10816518, 10816511, 10408904, 9218786

Clone :

D14HD11

Isotype :

IgG1

SPECIES REACTIVITY :

Human

Background :

CEA-related cell adhesion molecules (CEACAM) belong to the carcinoembryonic antigen (CEA) family. It consists of seven CEACAM (CEACAM1, CEACAM3-CEACAM8) and 11 pregnancy-specific glycoprotein (PSG1-PSG11) members. The CEA family proteins belong to the immunoglobulin (Ig) superfamily and are composed of one Ig variable-like (IgV) and a varying number (0-6) of Ig constant-like (IgC) domains. CEACAM molecules are membrane-bound either via a transmembrane domain or a glycosyl phosphatidyl inositol (GPI) anchor. CEACAM molecules are differentially expressed in epithelial cells or in leukocytes. Overexpression of CEA/CEACAM5 in tumors of epithelial origin is the basis of its wide-spread use as a tumor marker. The function of CEACAM family members varies widely: they function as cell adhesion molecules, tumor suppressors, regulators of lymphocytes and dendritic cell activation, receptors of Neisseria species and other bacteria.

ALTnames :

CD66a/CD66c/CD66d/CD66e/CGM7

Immunogen :

CEACAM5 partially purified from a perchloric acid extract from liver metastases of colonic tumors.

Specificity :

Recognizes CEACAM1, 3, 4, 5 and 6.

Buffer :

Liquid. In PBS, pH 7.2, containing 0.01% sodium azide.

Application Summary :

ELISA, FC, IHC (FS), WB

Storage :

-20°C