CD18 (human) monoclonal antibody (MEM-48) | Enzo Life Sciences ALX-805-062-C100 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

CD18 (human) monoclonal antibody (MEM-48)

catalog :

ALX-805-062-C100

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

MEM-48

The same clone is also sold as:

MyBioSource: MBS245100
Santa Cruz Biotechnology: sc-51652
OriGene: SM3103LE, SM3103F, SM3103APC, SM3103P, SM3103B, SM3103R, AM08244AF-N
Abnova: MAB0880, MAB4599, MAB4594, MAB4597, MAB4592
Invitrogen: MA1-19632, MA1-19564, MA1-19456, MA1-19492, A15701, MA1-19007, A15766, 37-1300
Exbio: 1A-216-T025, 1F-216-T100, A7-216-T025, 1B-216-C100, 12-216-C100, 1B-216-C025, 1A-216-T100, 1P-216-T100, 11-216-C025, 1F-216-T025, 1P-216-T025, A7-216-T100, 11-216-C100
Boster: M00458-2
Abcam: ab657
Novus Biologicals: NB500-379

reactivity :

human

application :

western blot, immunohistochemistry, immunoprecipitation, flow cytometry

citations: 8

Reference
Fukuda S, Schmid Schonbein G. Regulation of CD18 expression on neutrophils in response to fluid shear stress. Proc Natl Acad Sci U S A. 2003;100:13152-7 pubmed
Drbal K, Angelisova P, Hilgert I, Cerny J, Novak P, Horejsi V. A proteolytically truncated form of free CD18, the common chain of leukocyte integrins, as a novel marker of activated myeloid cells. Blood. 2001;98:1561-6 pubmed
Drbal K, Angelisova P, Cerny J, Hilgert I, Horejsi V. A novel anti-CD18 mAb recognizes an activation-related epitope and induces a high-affinity conformation in leukocyte integrins. Immunobiology. 2001;203:687-98 pubmed
Ottonello L, Epstein A, Mancini M, Amelotti M, Dapino P, Dallegri F. Monoclonal Lym-1 antibody-targeted lysis of B lymphoma cells by neutrophils. Evidence for two mechanisms of FcgammaRII-dependent cytolysis. J Leukoc Biol. 2000;68:662-8 pubmed
Drbal K, Angelisova P, Cerny J, Pavlistová D, Cebecauer M, Novak P, et al. Human leukocytes contain a large pool of free forms of CD18. Biochem Biophys Res Commun. 2000;275:295-9 pubmed
Ottonello L, Epstein A, Dapino P, Barbera P, Morone P, Dallegri F. Monoclonal Lym-1 antibody-dependent cytolysis by neutrophils exposed to granulocyte-macrophage colony-stimulating factor: intervention of FcgammaRII (CD32), CD11b-CD18 integrins, and CD66b glycoproteins. Blood. 1999;93:3505-11 pubmed
Bazil V, Stefanova I, Hilgert I, Kristofová H, Vanek S, Horejsi V. Monoclonal antibodies against human leucocyte antigens. IV. Antibodies against subunits of the LFA-1 (CD11a/CD18) leucocyte-adhesion glycoprotein. Folia Biol (Praha). 1990;36:41-50 pubmed
Cinek T, Horejsi V. The nature of large noncovalent complexes containing glycosyl-phosphatidylinositol-anchored membrane glycoproteins and protein tyrosine kinases. J Immunol. 1992;149:2262-70 pubmed

product information

Product ID :

ALX-805-062

Catalog Number :

ALX-805-062-C100

Product Name :

CD18 (human) monoclonal antibody (MEM-48)

Host species :

Mouse

Clonality :

Monoclonal

Product Type :

Antibody

Size :

100 µg

list of Pubmed id :

14595007, 11520808, 11402502, 11073105, 10964661, 10233903, 1971601, 1382093

Clone :

MEM-48

Isotype :

IgG1

SPECIES REACTIVITY :

Human

ALTnames :

β2 integrin

Immunogen :

Leukocytes from a patient suffering from a LGL-type leukemia.

Specificity :

Recognizes residues 534-546 in cysteine-rich repeat 3 of CD18 (β2 integrin).

Buffer :

Liquid. In PBS, pH 7.4, containing 15mM sodium azide.

Uses :

Functional Application: induces high-affinity LFA-1 conformation in leukocytes

Application Summary :

FC, IHC (FS), IP, WB, FUNC

Storage :

-20°C